Evaluation effect of silybum marianum, cynara scolymus L. and ziziphus jujube mill. Combination extract on non-alcoholic fatty liver in rats

Mohammadifar, M. and Behnam, M. and Talaei, S.A. and Khamechian, T. and Mehran, M. and Taghizadeh, M. (2018) Evaluation effect of silybum marianum, cynara scolymus L. and ziziphus jujube mill. Combination extract on non-alcoholic fatty liver in rats. Iranian Journal of Endocrinology and Metabolism, 19 (6). pp. 410-418.

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Introduction: Non-alcoholic fatty liver disease includes a spectrum of clinical syndromes from early steatosis to liver cirrhosis. The aim of this study was to evaluate the effect of combined extract of silymarin, artichoke and jujube on non-alcoholic fatty liver, induced by high-fat diet in rats. Materials and Methods: In this experimental study, 40 male rats were divided randomly into two groups, a sham group (n=8) and a high-fat diet group (n=32). After 4 months of being fed the high-fat diet, rats suffering from fatty liver were divided into 4 groups (n=8 each) including a high-fat diet group and the three groups receiving a dose of the combined extract 100, 200 and 400 mg/kg for 2 months. Finally, lipid profiles, activity of serum liver enzymes and liver histology were investigated. Results: The high-fat diet increased Chol, TG and LDL and decreased HDL levels (P<0.001). This diet also increased serum activity of ALT, AST and ALP to 84, 113 and 228, respectively. Receiving extract at doses of 200 and 400 mg/kg improved lipid profiles and hepatic enzyme activity (P<0.05). Histopathology confirmed changes in liver induced by the high fat diet and the protective effect of the extract. Conclusion: High-fat diet induced nonalcoholic fatty liver in rats and treatment with combined extracts of silymarin, artichoke and jujube improved the complications of the disease. © 2018, Endocrine Research Center. All rights reserved.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: cholesterol; Cynara scolymus extract; jujube extract; liver enzyme; low density lipoprotein; plant extract; Silybum marianum extract; triacylglycerol, alanine aminotransferase blood level; alkaline phosphatase blood level; animal model; Article; aspartate aminotransferase blood level; controlled study; enzyme activity; lipid diet; male; nonalcoholic fatty liver; nonhuman; rat
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Biochemistry
Depositing User: ART . editor
Date Deposited: 15 Apr 2019 12:37
Last Modified: 15 Apr 2019 12:37
URI: http://eprints.kaums.ac.ir/id/eprint/4003

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