The favorable effects of garlic intake on metabolic profiles, hs-CRP, biomarkers of oxidative stress and pregnancy outcomes in pregnant women at risk for pre-eclampsia: Randomized, double-blind, placebo-controlled trial

Aalami-Harandi, R. and Karamali, M. and Asemi, Z. (2015) The favorable effects of garlic intake on metabolic profiles, hs-CRP, biomarkers of oxidative stress and pregnancy outcomes in pregnant women at risk for pre-eclampsia: Randomized, double-blind, placebo-controlled trial. Journal of Maternal-Fetal and Neonatal Medicine, 28 (17). pp. 2020-2027.

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Abstract

Objective: This study was performed to determine the favorable effects of garlic on metabolic status and pregnancy outcomes among pregnant women at risk for pre-eclampsia.Methods: This randomized, double-blind, placebo-controlled trial was conducted among 44 pregnant women, primigravida, aged 18-40 years old at 27 weeks' gestation with positive roll-over test. Participants were randomly assigned to receive either one garlic tablet (equal to 400 mg garlic and 1 mg allicin) (n = 22) or placebo (n = 22) once daily for 9 weeks. Fasting blood samples were taken at baseline and after 9 weeks' intervention to measure metabolic profiles and biomarkers of oxidative stress.Results: Administration of garlic compared with the placebo resulted in decreased levels of serum high sensitivity C-reactive protein (hs-CRP) (-1425.90 versus 1360.50 ng/mL, p = 0.01) and increased plasma glutathione (GSH) (+98.10 versus. -49.87 μmol/l, p = 0.03). A trend toward a significant effect of garlic intake on reducing fasting plasma glucose (FPG) (p = 0.07), insulin (p = 0.09) and increasing quantitative insulin sensitivity check (QUICKI) (p = 0.05) was also observed.Conclusion: Consumption of garlic for 9 weeks among pregnant women at risk for pre-eclampsia led to decreased hs-CRP and increased GSH, but did not affect lipid profiles, total antioxidant capacity (TAC) and pregnancy outcomes. © 2014 © 2014 Informa UK Ltd.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: biological marker; C reactive protein; glucose; glutathione; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; triacylglycerol; biological marker; C reactive protein; glucose blood level; glutathione; insulin; placebo, adult; analytical parameters; Article; cholesterol blood level; clinical article; controlled study; diastolic blood pressure; diet supplementation; dietary intake; double blind procedure; female; garlic; gestational age; glucose blood level; high risk pregnancy; homeostatic model assessment for beta cell function; homeostatic model assessment for insulin resistance; human; insulin blood level; Iran; metabolic parameters; oxidative stress; preeclampsia; pregnancy outcome; pregnant woman; priority journal; protein blood level; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; systolic blood pressure; total antioxidant capacity; triacylglycerol blood level; adolescent; analysis; blood; diet; diet restriction; high risk pregnancy; insulin resistance; metabolome; oxidative stress; phytotherapy; Pre-Eclampsia; pregnancy; pregnancy outcome; young adult, Adolescent; Adult; Biomarkers; Blood Glucose; C-Reactive Protein; Diet; Double-Blind Method; Fasting; Female; Garlic; Glutathione; Humans; Insulin; Insulin Resistance; Iran; Metabolome; Oxidative Stress; Phytotherapy; Placebos; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Pregnancy, High-Risk; Young Adult
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 16:08
Last Modified: 07 Mar 2017 16:08
URI: http://eprints.kaums.ac.ir/id/eprint/388

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