Association of interleukin-10 -1082A>G (rs1800896) polymorphism with predisposition to breast cancer: A meta-analysis based on 17 case-control studies

Abedinzadeh, M. and Neamatzadeh, H. and Jafari, M. and Forat-Yazdi, M. and Nasiri, R. and Farahnak, S. and Foroughi, E. and Zare-Shehneh, M. (2018) Association of interleukin-10 -1082A>G (rs1800896) polymorphism with predisposition to breast cancer: A meta-analysis based on 17 case-control studies. Revista da Associacao Medica Brasileira, 64 (8). pp. 756-764.

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Abstract

INTRODUCTION: The association between the between IL-10 -1082A>G (rs1800896) polymorphism and breast cancer has been evaluated by several number case-control studies. However, these studies might be underpowered to reveal the true association. OBJECTIVE: We have performed a comprehensive meta-analysis to investigate the association IL-10 -1082A>G polymorphism and breast cancer. MATERIALS AND METHODS: A systematic literature search was conducted using PubMed, Google Scholar, and Web of Science up to September 20, 2017. Data was analysed with CMA software to identify the strength of the association by pooled odds ratios (ORs) with corresponding 95 confidence intervals (CIs). RESULTS: A total of 17 case-control studies involving 3275 cases and 3416 controls obtained from database searches were examined. Overall, there was no significant association between IL-10 -1082A>G polymorphism and breast cancer risk under all genetic models. No significant publication bias was found for the five genetic models (G vs. A: OR = 1.184, 95 CI = 0.895-1.180, p= 0.230; GG vs. AA: OR = 1.430, 95 CI = 0.927-2.204, p= 0.106; GA vs. AA: OR = 0.966, 95 CI = 0.765-1.221, p= 0.774; GG+GA vs. AA: OR = 0.957, 95 CI = 0.697-1.314, p= 0.786; and GG vs. GA+AA: OR = 1.221, 95 CI = 0.981-1.518, p= 0.073). Moreover, there was no significant association between the IL-10 -1082A>G polymorphism and breast cancer risk by ethnicity. CONCLUSION: Our findings indicated that IL-10 -1082A>G (rs1800896) polymorphism might not be a risk factor for the development of breast cancer. © 2018 Associacao Medica Brasileira. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: interleukin 10; interleukin 10, allele; amino acid substitution; Article; breast cancer; cancer risk; confidence interval; ethnicity; genetic association; genetic model; genetic polymorphism; genetic predisposition; genotype; human; immunopathogenesis; odds ratio; systematic review; breast tumor; case control study; female; gene frequency; genetics; meta analysis; risk factor, Breast Neoplasms; Case-Control Studies; Confidence Intervals; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Interleukin-10; Odds Ratio; Polymorphism, Genetic; Risk Factors
Subjects: Medicine
Biochemistry, Genetics and Molecular Biology
Immunology and Microbiology
Divisions: Faculty of Medicine > Basic Sciences > Applied Cell Sciences
Depositing User: ART . editor
Date Deposited: 17 Apr 2019 08:26
Last Modified: 17 Apr 2019 08:26
URI: http://eprints.kaums.ac.ir/id/eprint/3872

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