Physical, dosimetric and clinical aspects and delivery systems in neutron capture therapy

Farhood, B. and Samadian, H. and Ghorbani, M. and Zakariaee, S.S. and Knaup, C. (2018) Physical, dosimetric and clinical aspects and delivery systems in neutron capture therapy. Reports of Practical Oncology and Radiotherapy, 23 (5). pp. 462-473.

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Abstract

Neutron capture therapy (NCT) is a targeted radiotherapy for cancer treatment. In this method, neutrons with a spectra/specific energy (depending on the type of agent used for NCT) are captured with an agent that has a high cross-section with these neutrons. There are some agents that have been proposed in NCT including 10 B, 157 Gd and 33 S. Among these agents, only 10 B is used in clinical trials. Application of 157 Gd is limited to in-vivo and in-vitro research. In addition, 33 S has been applied in the field of Monte Carlo simulation. In BNCT, the only two delivery agents which are presently applied in clinical trials are BPA and BSH, but other delivery systems are being developed for more effective treatment in NCT. Neutron sources used in NCT are fission reactors, accelerators, and 252 Cf. Among these, fission reactors have the most application in NCT. So far, BNCT has been applied to treat various cancers including glioblastoma multiforme, malignant glioma, malignant meningioma, liver, head and neck, lung, colon, melanoma, thyroid, hepatic, gastrointestinal cancer, and extra-mammary Paget's disease. This paper aims to review physical, dosimetric and clinical aspects as well as delivery systems in NCT for various agents. © 2018 Greater Poland Cancer Centre

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: boron nitride nanotube; carbon nanotube; dendrimer; gadolinium; liposome; magnetic nanoparticle; metal nanoparticle; nanomaterial; nanoparticle; sulfur, boron neutron capture therapy; cancer radiotherapy; clinical practice; clinical study; dosimetry; gadolinium neutron capture therapy; human; malignant neoplasm; molecular weight; molecularly targeted therapy; nanotechnology; neutron; neutron capture therapy; nonhuman; physical chemistry; polymerization; Review; sulfur neutron capture therapy
Subjects: Medicine
Physics and Astronomy
Divisions: Faculty of Para medicine > Department of Management Radiology and Medical Physics
Depositing User: ART . editor
Date Deposited: 17 Apr 2019 09:25
Last Modified: 17 Apr 2019 09:25
URI: http://eprints.kaums.ac.ir/id/eprint/3864

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