Metabolic and genetic response to probiotics supplementation in patients with diabetic nephropathy: a randomized, double-blind, placebo-controlled trial

Mafi, A. and Namazi, G. and Soleimani, A. and Bahmani, F. and Aghadavod, E. and Asemi, Z. (2018) Metabolic and genetic response to probiotics supplementation in patients with diabetic nephropathy: a randomized, double-blind, placebo-controlled trial. Food and Function, 9 (9). pp. 4763-4770.

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This study was carried out to evaluate the effects of probiotics administration on the metabolic and genetic profiles in patients with diabetic nephropathy (DN). This was a randomized, placebo-controlled clinical trial with homeostasis model of assessment-estimated insulin resistance (HOMA-IR) as the primary and other metabolic profiles, and biomarkers of inflammation and oxidative stress as the secondary outcomes. This randomized, double-blind, placebo-controlled clinical trial was performed on 60 patients with DN. The patients were randomly assigned into two groups to receive either 8 � 109 CFU day�1 probiotic supplements or placebo (n = 30 in each group) for 12 weeks. Fasting blood was collected at the baseline and end of intervention to measure glycemic control, lipid profiles, biomarkers of inflammation and oxidative stress. Multiple linear regression models were used to assess the treatment effects on the outcomes adjusting for confounding variables. Probiotics supplementation, compared with the placebo, resulted in a significant reduction in fasting plasma glucose (P = 0.01), serum insulin concentrations (P = 0.01) and HOMA-IR (P = 0.007), and a significant increase in the quantitative insulin sensitivity check index (P = 0.04). Additionally, compared with the placebo, probiotic intake resulted in a significant reduction in triglycerides (P = 0.001) and total-/HDL-cholesterol ratio (P < 0.001), and a significant increase in HDL-cholesterol levels (P < 0.001). Supplementation with probiotics, compared with the placebo, was associated with a significant reduction in high-sensitivity C-reactive protein (P = 0.001), malondialdehyde (P < 0.001) and advanced glycation end products (P < 0.001), and a significant elevation in plasma total glutathione (P < 0.001). Overall, our study indicated that probiotics supplementation had beneficial effects on glycemic control and markers of cardio-metabolic risk. © The Royal Society of Chemistry.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: Biomarkers; Diseases; Insulin; Linear regression; Pathology, Advanced glycation end products; Beneficial effects; C-reactive proteins; Diabetic nephropathy; Insulin resistance; Insulin sensitivity; Metabolic profiles; Multiple linear regression models, Metabolism, biological marker; probiotic agent, aged; blood; cardiovascular disease; complication; controlled study; diabetic angiopathy; diabetic cardiomyopathy; diabetic nephropathy; double blind procedure; female; gene expression regulation; human; immunology; insulin dependent diabetes mellitus; insulin resistance; Iran; kidney; kidney failure; male; metabolism; middle aged; mononuclear cell; non insulin dependent diabetes mellitus; oxidative stress; pathophysiology; randomized controlled trial; risk; urine, Aged; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Cardiomyopathies; Diabetic Nephropathies; Double-Blind Method; Female; Gene Expression Regulation; Humans; Insulin Resistance; Iran; Kidney; Leukocytes, Mononuclear; Male; Middle Aged; Oxidative Stress; Probiotics; Renal Insufficiency; Risk
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 17 Apr 2019 10:19
Last Modified: 17 Apr 2019 10:19

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