The effects of vitamin D supplementation on endothelial activation among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials

Tabrizi, R. and Akbari, M. and Lankarani, K.B. and Heydari, S.T. and Kolahdooz, F. and Asemi, Z. (2018) The effects of vitamin D supplementation on endothelial activation among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials. Nutrition and Metabolism, 15 (1).

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Abstract

Background and objective: The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of vitamin D supplementation on endothelial activation among patients with metabolic syndrome and related disorders. Methods: Cochrane library, Embase, PubMed, and Web of Science database were searched to identify related RCTs published before 30th April 2018. The heterogeneity among the included studies was assessed using Cochran's Q test and I-square (I2) statistic. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as summary effect size. Results: Fourteen clinical trials that contained a total of 1253 participants were included in the current meta-analysis. Vitamin D supplementation significantly decreased von willebrand factor (vWF) (SMD -0.27; 95 CI, - 0.46, - 0.08; P = 0.006; I2:40.5). However, we found no significant impact of vitamin D supplementation on intercellular adhesion molecule 1(ICAM-1) (SMD -1.96; 95 CI, - 4.02, 0.09; P = 0.06; I2:97.4), vascular celladhesion molecule 1 (VCAM-1) (SMD -0.50; 95 CI, - 1.19, 0.19; P = 0.15; I2:91.2), on E-selectin (SMD -0.04; 95 CI, - 0.36, 0.28; P = 0.81; I2:78.8) and endothelin (SMD -0.49; 95 CI, - 1.18, 0.19; P = 0.15; I2:90.5). The pooled data from trials of vitamin D supplementation with dosage of �4000 IU/day (- 0.37, 95 CI: -0.65, - 0.10, I2: 73.5) significantly reduced vWF concentrations, while there was no effect of vitamin D supplementation on vWF concentrations among trials with the dosage of intervention > 4000 IU/day (- 0.17, 95 CI: -0.43, 0.10, I2: 0.0). VWF concentrations significantly reduced in pooled data from trials with duration study �8 weeks (- 0.37, 95 CI: -0.67, - 0.07, I2: 60.6), but there was no effect of vitamin D supplementation on vWF concentrations among trials with > 8 weeks (- 0.20, 95 CI: -0.45, 0.05, I2: 0.0). While there was no effect of vitamin D supplementation on vWF concentrations among trials with total sample size of �60 patients (- 0.03, 95 CI: -0.42, 0.36, I2: 0.0), vWF concentrations in trials with more than 60 patients decreased significantly (- 0.34, 95 CI: -0.56, - 0.12, I2: 60.9). Conclusions: Overall, the current meta-analysis demonstrated that vitamin D supplementation to patients with metabolic syndrome and related disorders resulted in an improvement in vWF, but did not affect ICAM-1, VCAM-1, E-selectin and endothelin levels. © 2018 The Author(s).

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: endothelial leukocyte adhesion molecule 1; endothelin; intercellular adhesion molecule 1; vascular cell adhesion molecule 1; vitamin D; von Willebrand factor, attenuation; body mass; clinical effectiveness; clinical protocol; human; meta analysis; metabolic syndrome X; quality control; randomized controlled trial (topic); Review; risk assessment; sensitivity analysis; systematic review; treatment duration; vitamin supplementation
Subjects: Health Professions
Divisions: Faculty of Para medicine > Department of Management & Health Information Technology
Depositing User: ART . editor
Date Deposited: 23 Apr 2019 09:01
Last Modified: 23 Apr 2019 09:01
URI: http://eprints.kaums.ac.ir/id/eprint/3805

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