The effects of melatonin administration on disease severity and sleep quality in children with atopic dermatitis: A randomized, double-blinded, placebo-controlled trial

Taghavi Ardakani, A. and Farrehi, M. and Sharif, M.R. and Ostadmohammadi, V. and Mirhosseini, N. and Kheirkhah, D. and Moosavi, S.G.A. and Behnejad, M. and Reiter, R.J. and Asemi, Z. (2018) The effects of melatonin administration on disease severity and sleep quality in children with atopic dermatitis: A randomized, double-blinded, placebo-controlled trial. Pediatric Allergy and Immunology, 29 (8). pp. 834-840.

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Abstract

Background: The aim of this clinical trial was to determine the effects of melatonin administration on disease severity and sleep quality in children diagnosed with atopic dermatitis (AD). Methods: This randomized, double-blinded, placebo-controlled trial was conducted by recruiting 70 patients, aged 6-12 years, who had been diagnosed with AD. Study participants were randomly allocated into two intervention groups to receive either 6 mg/d melatonin supplements or placebo (n = 35 each group) for 6 weeks. Severity of disease was assessed using the scoring atopic dermatitis (SCORAD) and objective SCORAD indices. Sleep quality was evaluated by completing the Children's Sleep Habits Questionnaire (CSHQ). Results: Following 6 weeks of intervention, melatonin supplementation significantly improved SCORAD index (β �3.55; 95 CI, �6.11, �0.98; P = 0.007), objective SCORAD index (β �3.23; 95 CI, �5.08, �1.38; P = 0.001), serum total IgE levels (β �153.94 ku/L; 95 CI, �260.39, �47.49; P = 0.005), and CSHQ scores (β �2.55; 95 CI, �4.34, �0.75; P = 0.006). However, melatonin had no significant impact on pruritus scores, high-sensitivity C-reactive protein (hs-CRP), sleep-onset latency, total sleep time, weight, and BMI compared with placebo. Conclusions: Overall, melatonin supplementation had beneficial effects on disease severity, serum total IgE levels, and CSHQ among children diagnosed with AD. © 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: C reactive protein; immunoglobulin E; melatonin; placebo; immunoglobulin E; melatonin, Article; atopic dermatitis; body mass; body weight change; child; Children's Sleep Habits Questionnaire; controlled study; disease severity; double blind procedure; drug efficacy; female; human; major clinical study; male; priority journal; questionnaire; randomized controlled trial; sleep latency; sleep quality; sleep time; supplementation; atopic dermatitis; blood; drug effect; Iran; pathophysiology; severity of illness index; sleep; treatment outcome, Child; Dermatitis, Atopic; Double-Blind Method; Female; Humans; Immunoglobulin E; Iran; Male; Melatonin; Severity of Illness Index; Sleep; Surveys and Questionnaires; Treatment Outcome
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Dermatology
Depositing User: ART . editor
Date Deposited: 23 Apr 2019 14:48
Last Modified: 23 Apr 2019 14:48
URI: http://eprints.kaums.ac.ir/id/eprint/3796

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