Glioblastoma cancer stem cell biology: Potential theranostic targets

Sharifzad, F. and Ghavami, S. and Mardpour, S. and Mollapour, M. and Azizi, Z. and Taghikhani, A. and �os, M.J. and Verdi, J. and Fakharian, E. and Ebrahimi, M. and Hamidieh, A.A. (2019) Glioblastoma cancer stem cell biology: Potential theranostic targets. Drug Resistance Updates, 42. pp. 35-45.

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Glioblastoma multiforme (GBM) is among the most incurable cancers. GBMs survival rate has not markedly improved, despite new radical surgery protocols, the introduction of new anticancer drugs, new treatment protocols, and advances in radiation techniques. The low efficacy of therapy, and short interval between remission and recurrence, could be attributed to the resistance of a small fraction of tumorigenic cells to treatment. The existence and importance of cancer stem cells (CSCs) is perceived by some as controversial. Experimental evidences suggest that the presence of therapy-resistant glioblastoma stem cells (GSCs) could explain tumor recurrence and metastasis. Some scientists, including most of the authors of this review, believe that GSCs are the driving force behind GBM relapses, whereas others however, question the existence of GSCs. Evidence has accumulated indicating that non-tumorigenic cancer cells with high heterogeneity, could undergo reprogramming and become GSCs. Hence, targeting GSCs as the �root cells� initiating malignancy has been proposed to eradicate this devastating disease. Most standard treatments fail to completely eradicate GSCs, which can then cause the recurrence of the disease. To effectively target GSCs, a comprehensive understanding of the biology of GSCs as well as the mechanisms by which these cells survive during treatment and develop into new tumor, is urgently needed. Herein, we provide an overview of the molecular features of GSCs, and elaborate how to facilitate their detection and efficient targeting for therapeutic interventions. We also discuss GBM classifications based on the molecular stem cell subtypes with a focus on potential therapeutic approaches. © 2019

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: beta catenin; sonic hedgehog protein; Wnt protein, Article; cancer classification; cancer recurrence; cancer stem cell; cell isolation; cytology; epigenetics; glioblastoma; human; Notch signaling; priority journal; tumor microenvironment; Wnt signaling
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Applied Cell Sciences
Depositing User: ART . editor
Date Deposited: 27 Apr 2019 13:44
Last Modified: 27 Apr 2019 13:44

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