Metabolic response to selenium supplementation in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial

Jamilian, M. and Razavi, M. and Fakhrie-Kashan, Z. and Ghandi, Y. and Bagherian, T. and Asemi, Z. (2015) Metabolic response to selenium supplementation in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Clinical Endocrinology, 82 (6). pp. 885-891.

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Abstract

Objective We are aware of no study examining the effects of selenium supplementation on metabolic profiles of patients with polycystic ovary syndrome (PCOS). This study was conducted to evaluate the effects of selenium supplementation on glucose homeostasis parameters and lipid concentrations in women with PCOS. Design, patients and measurements This randomized, double-blind, placebo-controlled trial was conducted among 70 women diagnosed with PCOS and aged 18-40 years old. Participants were randomly divided into two groups to receive 200 μg per day selenium supplements (N = 35) or placebo (N = 35) for 8 weeks. Fasting blood samples were taken at baseline and after 8 weeks intervention to quantify glucose, insulin and lipid concentrations. Results After 8 weeks of intervention, subjects who received selenium supplements had significantly decreased serum insulin levels (-29·83 ± 47·29 vs +9·07 ± 77·12 pmol/l, P = 0·013), homeostasis model of assessment-insulin resistance (HOMA-IR) (-1·15 ± 1·81 vs +0·42 ± 3·09, P = 0·011), homeostatic model assessment-beta-cell function (HOMA-B) (-19·06 ± 30·95 vs +4·55 ± 47·99, P = 0·017) and increased quantitative insulin sensitivity check index (QUICKI) (+0·03 ± 0·04 vs +0·0009 ± 0·05, P = 0·032) compared with placebo. In addition, supplementation with selenium resulted in a significant reduction in serum triglycerides (-0·14 ± 0·55 vs +0·11 ± 0·30 mmol/l, P = 0·025) and VLDL-C concentrations (-0·03 ± 0·11 vs +0·02 ± 0·06 mmol/l, P = 0·025) compared with placebo. Conclusions In conclusion, 200 microgram per day selenium supplementation for 8 weeks among PCOS women had beneficial effects on insulin metabolism parameters, triglycerides and VLDL-C levels; however, it did not affect FPG and other lipid profiles. © 2014 John Wiley & Sons Ltd.

Item Type: Article
Additional Information: cited By 11
Uncontrolled Keywords: cellulose; glucose; insulin; placebo; selenium; triacylglycerol; very low density lipoprotein cholesterol; C reactive protein; glucose blood level; insulin; selenium; trace element; triacylglycerol, absence of side effects; adult; Article; clinical evaluation; controlled study; diet supplementation; double blind procedure; drug effect; female; glucose blood level; glucose homeostasis; gluhomeostatic model assessment of beta cell function; homeostatic model assessment of insulin resistance; human; insulin blood level; insulin metabolism; insulin sensitivity; major clinical study; metabolic parameters; metabolism; outcome assessment; ovary polycystic disease; priority journal; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; statistical analysis; treatment outcome; triacylglycerol blood level; adolescent; blood; dietary supplement; drug monitoring; insulin resistance; metabolism; Polycystic Ovary Syndrome, Adolescent; Adult; Blood Glucose; C-Reactive Protein; Dietary Supplements; Double-Blind Method; Drug Monitoring; Female; Humans; Insulin; Insulin Resistance; Polycystic Ovary Syndrome; Selenium; Trace Elements; Treatment Outcome; Triglycerides
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 16:28
Last Modified: 07 Mar 2017 16:28
URI: http://eprints.kaums.ac.ir/id/eprint/377

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