Molecular pathogenesis of interstitial cystitis/bladder pain syndrome based on gene expression

Karamali, M. and Shafabakhsh, R. and Ghanbari, Z. and Eftekhar, T. and Asemi, Z. (2019) Molecular pathogenesis of interstitial cystitis/bladder pain syndrome based on gene expression. Journal of Cellular Physiology.

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Interstitial cystitis/painful bladder syndrome (IC/PBS) is a chronic bladder inflammation that leads to chronic bladder pain and urinary urgency and frequency. The presentation of IC/PBS is heterogeneous, and it is classified as ulcerative IC/PBS and nonulcerative IC/PBS. The main cause of IC/PBS is thought to be a persistent inflammatory condition in the bladder, though the actual pathophysiology has not been identified yet. Although the underlying pathophysiology of IC/PBS is not completely understood, several theories for the etiology of this syndrome have been suggested, including deficiency of the glycosaminoglycan covering urothelium surface that results in leaky urothelium infection, immunological etiology, activated mast cells, neural changes, and inflammation. In addition, there are no gold standards for the detection of this disorder to date. So, determination of gene expression and its role in different signaling pathways in the pathogenesis of this heterogeneous disorder contribute to the more efficient cognition of the pathophysiology of this disease and to the design of effective treatments and molecular diagnostic methods for IC/PBS. © 2019 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 0; Article in Press
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Applied Cell Sciences
Depositing User: ART . editor
Date Deposited: 07 May 2019 09:04
Last Modified: 07 May 2019 09:04

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