Effects of folate supplementation on carotid intima-media thickness, biomarkers of inflammation, and oxidative stress in carbamazepine-treated epileptic children

Talari, H.R. and Bahrami, M. and Ardestani, A.T. and Bahmani, F. and Famili, P. and Asemi, Z. (2019) Effects of folate supplementation on carotid intima-media thickness, biomarkers of inflammation, and oxidative stress in carbamazepine-treated epileptic children. International Journal of Preventive Medicine, 10 (1).

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Abstract

Background: This study was conducted to assess the effects of folate supplementation on carotid intima-media thickness (CIMT), biomarkers of inflammation, and oxidative stress in carbamazepine-treated epileptic children. Methods: This randomized, double-blind, placebo-controlled trial was carried out in 54 epileptic children aged 2-12 years old receiving carbamazepine monotherapy. Participants were randomly allocated into two groups to receive either 5 mg folate supplements or placebo (n = 27 in each group) for 12 weeks. Results: After the 12-week intervention, compared with the placebo, folate supplementation resulted in a significant reduction in plasma homocysteine (Hcy) (changes from baseline - 2.1 ± 2.5 vs. +0.1 ± 0.4 μmol/L, P < 0.001), serum high-sensitivity C-reactive protein (hs-CRP) (changes from baseline - 1.5 ± 3.5 vs. +0.4 ± 1.4 mg/L, P = 0.01), a significant increase in plasma nitric oxide (NO) (changes from baseline + 1.9 ± 5.8 vs. -2.0 ± 6.4 μmol/L, P = 0.02), and total antioxidant capacity (TAC) concentrations (changes from baseline + 88.6 ± 116.0 vs. +1.8 ± 77.4 mmol/L, P = 0.002). We did not observe any significant effects in mean levels of left and right CIMT, maximum levels of left and right CIMT, and total glutathione (GSH) and malondialdehyde (MDA) levels following the supplementation of folate compared with the placebo. Conclusions: Overall, folate supplementation at a dosage of 5 mg/day for 12 weeks among epileptic children receiving carbamazepine had beneficial effects on Hcy, hs-CRP, NO, and TAC levels, but did not affect CIMT, and GSH and MDA levels. © 2019 Wolters Kluwer Medknow Publications. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: biological marker; C reactive protein; carbamazepine; folic acid; glutathione; homocysteine; malonaldehyde; nitric oxide; placebo, antioxidant activity; arterial wall thickness; Article; child; controlled study; double blind procedure; epilepsy; female; human; inflammation; major clinical study; male; monotherapy; oxidative stress; randomized controlled trial; school child; supplementation
Subjects: Medicine
Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 07 May 2019 09:19
Last Modified: 07 May 2019 09:19
URI: http://eprints.kaums.ac.ir/id/eprint/3739

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