Correlation between CRP and beta-2 microglobulin in chronic hemodialysis patients with high-flux membrane

Rahbar, M. and Chitsazian, Z. and Moslemi, B. and Ramim, T. (2015) Correlation between CRP and beta-2 microglobulin in chronic hemodialysis patients with high-flux membrane. Tehran University Medical Journal, 73 (1). pp. 49-54.

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Background: One of the toxins accumulated in the body of hemodialysis patients is beta 2 microglobulin which is caused and increased by various factors. The one of this factors that can affect beta-2 macroglobulin is of membrane type that using in hemodialysis. In the present study, we examined the impact of C-reactive protein (CRP) as an inflammatory factor on beta-2 microglobulin in high-flux membrane hemodialysis patients. Methods: This cross-sectional study was done in 44 hemodialysis patients that have been dialyzed in two academic centers; Sina and Amir Alam Hospitals, Tehran, Iran from 2013 to 2014. The patients were hemodialyzed via fistula or permanent catheters three times a week for 4 hours for more than three months. Patients with known infectious disease, hemodialysis with low-flux membrane and dialysis less than three times a week were excluded. All patients were hemodialyzed using Fresenius biocompatible high-flux membrane (FX 100, Fresenius, Massachusetts, USA). Arterial blood sampling was performed. beta-2 microglobulin, CRP, BUN and creatinine tests were conducted for all patients. Results: Forty-four patients among the chronic hemodialysis patients were selected for final analysis. 20 males (44.5) and 24 females (54.5) were included in this study. The frequencies of underlying disease in patients participating in the study were as follows: hypertension, 23 cases (52.3); diabetes mellitus, 11 cases (25); hypertension and diabetes mellitus, 2 cases (4.5); obstructive disorder, 2 cases (4.5). In 23 patients (52.3), beta-2 macroglobulin was >12 mg/l and in 21 (47.7), it was <12 mg/l. 29 cases (65.9) had CRP values less than or equal 6 mg/l. However, there was no significant differences between beta-2 microglobulin and CRP levels (P= 0.460). Also regression analysis of data showed no relationship between beta-2 microglobulin and CRP levels (r= -047, P= 0.763). Conclusion: Although it seems that inflammatory factors can be effective in increasing beta-2 microglobulin, the present study did not find such a relationship between CRP and beta-2 microglobulin. © 2015, Tehran University of Medical Sciences. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: beta 2 microglobulin; C reactive protein, Article; clinical article; cross-sectional study; dialysis membrane; female; hemodialysis; human; male
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Internal Medicine
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 16:25
Last Modified: 11 Mar 2017 14:55

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