The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials

Tabrizi, R. and Vakili, S. and Akbari, M. and Mirhosseini, N. and Lankarani, K.B. and Rahimi, M. and Mobini, M. and Jafarnejad, S. and Vahedpoor, Z. and Asemi, Z. (2019) The effects of curcumin-containing supplements on biomarkers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Phytotherapy Research, 33 (2). pp. 253-262.

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Abstract

Besides other benefits, curcumin is getting more recognized for its antioxidant and anti-inflammatory properties, highlighting the importance of curcumin application for chronic disease prevention. This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to assess the influence of curcumin-containing supplements on biomarkers of inflammation and oxidative stress. MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials were searched till January 2018 for eligible studies. The selected studies were evaluated for their quality using the Cochrane risk of bias tool and relevant data were extracted from included studies. Data were pooled using the inverse variance method and expressed as standardized mean difference (SMD) with 95 confidence intervals (95 CI). Fifteen RCTs were included in the final analysis. The meta-analysis indicated that curcumin supplementation significantly decreased interleukin 6 (IL-6) (SMD �2.08; 95 CI �3.90, �0.25; p = 0.02), high-sensitivity C-reactive protein (hs-CRP) (SMD �0.65; 95% CI �1.20, �0.10, p = 0.02), and malondialdehyde (MDA) concentrations (SMD �3.14; 95% CI -4.76, �1.53, p < 0.001). Though, curcumin supplementation had no significant effect on tumor necrosis factor-alpha (SMD �1.62; 95% CI �3.60, 0.36; p = 0.10) and superoxide dismutase levels (SMD 0.34; 95% CI �1.06, 1.74, p = 0.63). Overall, this meta-analysis suggests that taking curcumin-containing supplements may exert anti-inflammatory and antioxidant properties through a significant reduction in IL-6, hs-CRP, and MDA levels. © 2018 John Wiley & Sons, Ltd.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: biological marker; C reactive protein; curcumin; interleukin 6; malonaldehyde; metformin, antiinflammatory activity; antioxidant activity; chronic disease; concentration (parameter); coronary artery disease; diabetes mellitus; diabetic nephropathy; human; hyperlipidemia; inflammation; meta analysis; metabolic disorder; metabolic syndrome X; non insulin dependent diabetes mellitus; obesity; oxidative stress; randomized controlled trial (topic); Review; sensitivity analysis; supplementation; systematic review; vascular disease
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 07 May 2019 11:55
Last Modified: 07 May 2019 11:55
URI: http://eprints.kaums.ac.ir/id/eprint/3726

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