Effect of cinnamon (Cinnamomum Zeylanicum) supplementation on serum C-reactive protein concentrations: A meta-analysis and systematic review

Vallianou, N. and Tsang, C. and Taghizadeh, M. and Davoodvandi, A. and Jafarnejad, S. (2019) Effect of cinnamon (Cinnamomum Zeylanicum) supplementation on serum C-reactive protein concentrations: A meta-analysis and systematic review. Complementary Therapies in Medicine, 42. pp. 271-278.

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Objective: The effect of cinnamon (Cinnamomum Zeylanicum) on serum C-reactive protein (CRP), an acute phase protein commonly used as a marker of inflammation, is uncertain. Therefore, the objective of the present study was to conduct a systematic review and meta-analysis of published randomised controlled trials (RCTs) of cinnamon to determine the effect on levels of serum CRP, relative to controls. Design: Studies were identified by a search of electronic databases including PubMed, Cochrane Library, Google Scholar and Scopus before August 2018. Combined and stratified analyses were used. Weighted mean differences (WMD) and its 95 confidence interval were estimated for net change in serum CRP by using random-effects model. The heterogeneity of meta-analysis was assessed by � 2 and I 2 test. Results: Six studies were identified, and data from 285 participants were included. Pooled analysis showed significant reductions in serum CRP (WMD: �0.81 mg/L, 95 CI: �1.36 to �0.26, p = 0.004), with significant heterogeneity between selected studies. Improvements in sub-group analysis were observed when baseline CRP levels were greater than 3 mg/dL, and in trials of >12 weeks duration. Doses <1500 mg/day and �1500 mg/day were effective in lowering serum CRP (WMD: �0.56 mg/dL, 95 CI: �1.01 to -0.10, p = 0.02 and WMD: �2.13 mg/dL, 95 CI: �4.08 to �0.19, p = 0.03), respectively, with significantly reduced heterogeneity in trials with lower doses of cinnamon <1500 mg/day (test for heterogeneity: P = 0.22 and I2 = 33). No changes were found in controls. Conclusion: Cinnamon supplementation improves levels of serum CRP, particularly in chronic conditions, where basal CRP levels are raised. Further well-designed studies are warranted to confirm or not the above-mentioned findings. © 2018 Elsevier Ltd

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: C reactive protein, Cinnamomum zeylanicum; human; inflammation; nonhuman; protein blood level; quality control; randomized controlled trial (topic); Review; sensitivity analysis; supplementation; systematic review
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Biochemistry
Depositing User: ART . editor
Date Deposited: 12 May 2019 13:47
Last Modified: 12 May 2019 13:47
URI: http://eprints.kaums.ac.ir/id/eprint/3721

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