Stem cell-based therapy for Parkinson�s disease with a focus on human endometrium-derived mesenchymal stem cells

Bagheri-Mohammadi, S. and Karimian, M. and Alani, B. and Verdi, J. and Tehrani, R.M. and Noureddini, M. (2019) Stem cell-based therapy for Parkinson�s disease with a focus on human endometrium-derived mesenchymal stem cells. Journal of Cellular Physiology, 234 (2). pp. 1326-1335.

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Abstract

Parkinson�s disease (PD) as an increasing clinical syndrome is a multifunctional impairment with systemic involvement. At present, therapeutic approaches such as l-3,4-dihydroxy-phenylalanine replacement therapy, dopaminergic agonist administration, and neurosurgical treatment intend to relieve PD symptoms which are palliative and incompetent in counteracting PD progression. These mentioned therapies have not been able to replace the lost cells and they could not effectively slow down the relentless neurodegenerative process. Till now, there is a lack of eligible treatment for PD, and stem cells therapy recently has been considered for PD treatment. In this review, we demonstrate how human stem cell technology especially human endometrium-derived stem cells have made advancement as a therapeutic source for PD compared with other treatments. © 2018 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: antiparkinson agent, cord blood stem cell transplantation; endometrium cell; female; gene therapy; human; human embryonic stem cell; induced pluripotent stem cell; mesenchymal stem cell; mesenchymal stem cell transplantation; neural stem cell; nonhuman; Parkinson disease; priority journal; Review
Subjects: Pathology
Divisions: Faculty of Medicine > Basic Sciences > Department of Pathology& Histology
Depositing User: ART . editor
Date Deposited: 11 May 2019 11:13
Last Modified: 11 May 2019 11:13
URI: http://eprints.kaums.ac.ir/id/eprint/3716

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