Chemopreventive and therapeutic potential of curcumin in esophageal cancer: Current and future status

Hesari, A. and Azizian, M. and Sheikhi, A. and Nesaei, A. and Sanaei, S. and Mahinparvar, N. and Derakhshani, M. and Hedayt, P. and Ghasemi, F. and Mirzaei, H. (2019) Chemopreventive and therapeutic potential of curcumin in esophageal cancer: Current and future status. International Journal of Cancer, 144 (6). pp. 1215-1226.

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Esophageal cancer is a common malignant tumor with an increasing trend during the past three decades. Currently, esophagectomy, often in combination with neoadjuvant chemo- and radiotherapy, is the cornerstone of curative treatment for esophageal cancer. However, esophagostomy is related to significant risks of perioperative mortality and morbidity, as well as lengthy recovery. Moreover, the adjuvant therapies including chemotherapy and radiotherapy are associated with numerous side effects, limiting compliance and outcome. The dietary agent curcumin has been extensively studied over the past few decades and is known to have many biological activities especially in regard to the prevention and potential treatment of cancer. This review summarizes the chemo-preventive and chemotherapeutic potential of curcumin in esophageal cancer in both preclinical and clinical settings. © 2018 UICC

Item Type: Article
Additional Information: cited By 11
Uncontrolled Keywords: curcumin; microRNA, antineoplastic activity; carcinogenesis; chemoprophylaxis; clinical study; drug effect; drug efficacy; drug structure; esophageal cancer cell line; esophagus cancer; human; in vitro study; in vivo study; nonhuman; priority journal; Review
Subjects: Medicine
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 25 May 2019 11:22
Last Modified: 25 May 2019 11:22

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