Tempol improves oxidant/antioxidant parameters in testicular tissues of diabetic rats

Shateri, H. and Ranjbar, A. and Kheiripour, N. and Ghasemi, H. and Pourfarjam, Y. and Habibitabar, E. and Gholami, H. and Moridi, H. (2019) Tempol improves oxidant/antioxidant parameters in testicular tissues of diabetic rats. Life Sciences, 221. pp. 65-71.

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Abstract

Aims: Oxidative stress induced by diabetes mellitus (DM) is considered as one of the main causes of infertility in diabetic patients. The aim of the present study was to assess the effect of Tempol � as a synthetic antioxidant- on the testis oxidative stress and sperm parameters in type 2 diabetic (T2D) rats. Main methods: Twenty male Wistar rats were divided into 4 groups. Control groups (C) and diabetic groups (D); the control and diabetic groups received Tempol (100 mg/kg) for one month. Sperm parameters and oxidative stress biomarkers were evaluated in testicular tissue. Key findings: The results demonstrated that administration of Tempol in diabetic rats improved sperm motility and viability and decreased the count of abnormal sperms. Also Tempol decreased the fasting blood sugar (FBS) and lipid peroxidation (LPO). In addition, Tempol significantly increased total antioxidant capacity (TAC) levels in testis tissue of T2D rats. Histopathological changes were also improved in the diabetic treated group. Significance: Taken together, the results indicated that Tempol improved fertility parameters in a diabetic rat through reducing oxidative stress. © 2019 Elsevier Inc.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: glucose; malonaldehyde; tempol; thiol; amine oxide; antioxidant; catalase; glutathione peroxidase; spin label; superoxide dismutase; tempol, animal cell; animal experiment; animal model; Article; body weight; cell viability; controlled study; disease severity; drug efficacy; drug response; giant cell; glucose blood level; histopathology; Leydig cell; lipid peroxidation; male; non insulin dependent diabetes mellitus; nonhuman; oxidative stress; rat; seminiferous tubule; Sertoli cell; spermatid; spermatogonium; spermatozoon count; spermatozoon motility; testis tissue; animal; drug effect; experimental diabetes mellitus; metabolism; physiology; spermatozoon; spermatozoon count; spermatozoon motility; testis; Wistar rat, Animals; Antioxidants; Catalase; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Glutathione Peroxidase; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar; Sperm Count; Sperm Motility; Spermatozoa; Spin Labels; Superoxide Dismutase; Testis
Subjects: Pathology
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Biochemistry
Depositing User: ART . editor
Date Deposited: 25 May 2019 11:16
Last Modified: 25 May 2019 11:16
URI: http://eprints.kaums.ac.ir/id/eprint/3680

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