Zinc supplementation and the effects on metabolic status in gestational diabetes: A randomized, double-blind, placebo-controlled trial

Karamali, M. and Heidarzadeh, Z. and Seifati, S.M. and Samimi, M. and Tabassi, Z. and Hajijafari, M. and Asemi, Z. and Esmaillzadeh, A. (2015) Zinc supplementation and the effects on metabolic status in gestational diabetes: A randomized, double-blind, placebo-controlled trial. Journal of Diabetes and its Complications, 29 (8). pp. 1314-1319.

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Abstract

Objective To the best of our knowledge, no reports are available indicating the effects of zinc supplementation on metabolic status in women with gestational diabetes (GDM). This study was designed to determine the effects of zinc supplementation on glucose homeostasis parameters and lipid concentrations in GDM women. Methods This randomized, double-blind, placebo-controlled trial was performed among 58 women diagnosed with GDM, primigravida and aged 18-40 years old. Patients were randomly divided into two groups to receive 233 mg zinc gluconate (containing 30 mg zinc) supplements (n = 29) or placebo (n = 29) per day for 6 weeks. Fasting blood samples were taken at the beginning and end of the trial to quantify glucose, insulin and lipid concentrations. Results Patients who received zinc supplements had significantly higher serum zinc concentrations (+ 6.9 ± 13.2 vs. - 1.5 ± 16.5 mg/dL, P = 0.03) than those received the placebo. In addition, zinc-supplemented patients had reduced fasting plasma glucose (FPG) (- 6.6 ± 11.2 vs. + 0.6 ± 6.7 mg/dL, P = 0.005), serum insulin levels (- 1.3 ± 6.6 vs. + 6.6 ± 12.2 μIU/mL, P = 0.003), homeostasis model of assessment-insulin resistance (HOMA-IR) (- 0.5 ± 1.6 vs. + 1.5 ± 2.7, P = 0.001), homeostatic model assessment-Beta cell function (HOMA-B) (- 0.7 ± 25.0 vs. + 26.5 ± 49.5, P = 0.01) and increased quantitative insulin sensitivity check index (QUICKI) (+ 0.01 ± 0.01 vs. - 0.01 ± 0.02, P = 0.004) compared with the placebo. Additionally, significant differences in serum triglycerides (+ 13.6 ± 61.4 vs. + 45.9 ± 36.5 mg/dL, P = 0.01) and VLDL-cholesterol concentrations (+ 2.7 ± 12.3 vs. + 9.2 ± 7.3 mg/dL, P = 0.01) were observed following the administration of zinc supplements compared with the placebo.We did not observe any significant effects of taking zinc supplements on other lipid profiles. Conclusions Taken together, 30 mg zinc supplementation per day for 6 weeks among GDM women had beneficial effects on metabolic profiles. © 2015 Elsevier Inc. All rights reserved.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: carbohydrate; gluconate zinc; glucose; insulin; lipid; placebo; triacylglycerol; very low density lipoprotein cholesterol; biological marker; gluconic acid; glucose blood level; zinc, adult; Article; assessment of humans; blood sampling; cell function; clinical assessment; clinical evaluation; comparative study; controlled study; diet restriction; diet supplementation; dietary intake; female; glucose blood level; glucose homeostasis; homeostasis model assessment insulin resistance; human; insulin blood level; insulin metabolism; insulin resistance; major clinical study; outcome assessment; pancreas islet beta cell; pregnancy diabetes mellitus; primigravida; priority journal; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; triacylglycerol blood level; zinc blood level; analysis; blood; diet therapy; dietary supplement; double blind procedure; follow up; hyperglycemia; hypertriglyceridemia; insulin resistance; intention to treat analysis; Iran; maternal nutrition; metabolism; patient dropout; pregnancy; Pregnancy Complications; pregnancy diabetes mellitus; second trimester pregnancy; young adult, Adult; Biomarkers; Blood Glucose; Diabetes, Gestational; Dietary Supplements; Double-Blind Method; Female; Gluconates; Humans; Hyperglycemia; Hypertriglyceridemia; Insulin Resistance; Intention to Treat Analysis; Iran; Lost to Follow-Up; Maternal Nutritional Physiological Phenomena; Patient Dropouts; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Second; Young Adult; Zinc
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 15:57
Last Modified: 07 Mar 2017 15:57
URI: http://eprints.kaums.ac.ir/id/eprint/368

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