Calcium plus vitamin D supplementation affects glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome

Asemi, Z. and Foroozanfard, F. and Hashemi, T. and Bahmani, F. and Jamilian, M. and Esmaillzadeh, A. (2015) Calcium plus vitamin D supplementation affects glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome. Clinical Nutrition, 34 (4). pp. 586-592.

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Abstract

Background & aims: Few studies have examined the effects of calcium plus vitamin D supplementation on glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome (PCOS). This study was conducted to determine the effects of calcium plus vitamin D supplementation on glucose metabolism and lipid concentrations among overweight and obese vitamin D deficient women with PCOS. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 104 overweight and obese vitamin D deficient women diagnosed with PCOS. Participants were randomly assigned into four groups to receive: 1) 1000mg/d calcium+vitamin D placebo (. n=26); 2) 50,000IU/wk vitamin D+calcium placebo (. n=26); 3) 1000mg calcium/d+50,000IU/wk vitamin D (. n=26) and 4) calcium placebo+vitamin D placebo (. n=26) for 8 weeks. Fasting blood samples were taken at baseline and after 8 weeks' intervention to measure glucose metabolism and lipid concentrations. Results: Calcium-vitamin D co-supplementation resulted in higher levels of serum calcium (. P=0.002) and vitamin D (. P<0.001) compared with other groups. Co-supplementation, compared with other groups, led to decreased serum insulin levels (. P=0.03), homeostasis model of assessment-insulin resistance (HOMA-IR) score (. P=0.04) and a significant rise in quantitative insulin sensitivity check index (QUICKI) (. P=0.001). Furthermore, a significant decrease in serum triglycerides (. P=0.02) and VLDL-cholesterol levels (. P=0.02) was seen following the administration of calcium plus vitamin D supplements compared with the other groups. Co-supplementation with calcium and vitamin D had no significant effects on FPG, total-, LDL-, HDL-, and non-HDL-cholesterol levels. Conclusions: In conclusion, calcium plus vitamin D supplementation for eight weeks among vitamin D deficient women with PCOS had beneficial effects on serum insulin levels, HOMA-IR, QUICKI, serum triglycerides and VLDL-cholesterol levels, but it did not affect FPG and other lipid profiles.Clinical registration number. www.irct.ir: IRCT201309275623N10. © 2014 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.

Item Type: Article
Additional Information: cited By 14
Uncontrolled Keywords: calcium; colecalciferol; high density lipoprotein cholesterol; insulin; lipid; low density lipoprotein cholesterol; placebo; triacylglycerol; very low density lipoprotein cholesterol; vitamin D; calcium intake; glucose blood level; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; triacylglycerol; vitamin D, adult; Article; blood sampling; calcium blood level; cholesterol blood level; controlled study; diet restriction; double blind procedure; female; glucose metabolism; human; insulin blood level; insulin resistance; insulin sensitivity; lipid blood level; major clinical study; obesity; ovary polycystic disease; quantitative analysis; randomized controlled trial; scoring system; treatment duration; triacylglycerol blood level; vitamin blood level; vitamin D deficiency; vitamin supplementation; administration and dosage; adolescent; blood; body mass; calcium intake; caloric intake; carbohydrate metabolism; dietary supplement; drug effects; glucose blood level; lipid metabolism; metabolism; obesity; Overweight; Polycystic Ovary Syndrome; vitamin D deficiency; waist circumference; young adult, Adolescent; Adult; Blood Glucose; Body Mass Index; Calcium, Dietary; Carbohydrate Metabolism; Cholesterol, HDL; Cholesterol, LDL; Dietary Supplements; Double-Blind Method; Energy Intake; Fasting; Female; Humans; Insulin; Insulin Resistance; Lipid Metabolism; Obesity; Overweight; Polycystic Ovary Syndrome; Triglycerides; Vitamin D; Vitamin D Deficiency; Waist Circumference; Young Adult
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 17:10
Last Modified: 07 Mar 2017 17:10
URI: http://eprints.kaums.ac.ir/id/eprint/367

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