The effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial

Afzali, H. and Jafari Kashi, A.H. and Momen-Heravi, M. and Razzaghi, R. and Amirani, E. and Bahmani, F. and Gilasi, H.R. and Asemi, Z. (2019) The effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial. Wound Repair and Regeneration, 27 (3). pp. 277-284.

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Abstract

This study was carried out to determine the effects of magnesium and vitamin E co-supplementation on wound healing and metabolic status in patients with diabetic foot ulcer (DFU). The current randomized, double-blind, placebo-controlled trial was conducted among 57 patients with grade 3 DFU. Participants were randomly divided into two groups to take either 250 mg magnesium oxide plus 400 IU vitamin E (n = 29) or placebo per day (n = 28) for 12 weeks. Compared with the placebo, taking magnesium plus vitamin E supplements reduced ulcer length (β difference in the mean of outcomes measures between treatment groups �0.56 cm; 95% CI, �0.92, �0.20; p = 0.003), width (β �0.35 cm; 95% CI, �0.64, �0.05; p = 0.02) and depth (β �0.18 cm; 95% CI, �0.33, �0.02; p = 0.02). In addition, co-supplementation led to a significant reduction in fasting plasma glucose (β �13.41 mg/dL; 95% CI, �20.96, �5.86; p = 0.001), insulin (β �1.45 μIU/ml; 95% CI, �2.37, �0.52; p = 0.003), insulin resistance (β �0.60; 95% CI, �0.99, �0.20; p = 0.003) and HbA1c (β �0.32%; 95% CI, �0.48, �0.16; p < 0.003), and a significant elevation in insulin sensitivity (β 0.007; 95% CI, 0.003, 0.01; p < 0.001) compared with the placebo. Additionally, compared with the placebo, taking magnesium plus vitamin E supplements decreased triglycerides (β �10.08 mg/dL; 95% CI, �19.70, �0.46; p = 0.04), LDL-cholesterol (β �5.88 mg/dL; 95% CI, �11.42, �0.34; p = 0.03), high sensitivity C-reactive protein (hs-CRP) (β �3.42 mg/L; 95% CI, �4.44, �2.41; p < 0.001) and malondialdehyde (MDA) (β �0.30 μmol/L; 95% CI, �0.45, �0.15; p < 0.001), and increased HDL-cholesterol (β 2.62 mg/dL; 95% CI, 0.60, 4.63; p = 0.01) and total antioxidant capacity (TAC) levels (β 53.61 mmol/L; 95% CI, 4.65, 102.57; p = 0.03). Overall, magnesium and vitamin E co-supplementation for 12 weeks to patients with DFU had beneficial effects on ulcer size, glycemic control, triglycerides, LDL- and HDL-cholesterol, hs-CRP, TAC, and MDA levels. © 2019 by the Wound Healing Society

Item Type: Article
Additional Information: cited By 0
Subjects: Medicine
Nutrition
Divisions: Faculty of Medicine > Clinical Sciences > Department of Infectious Diseases
Depositing User: ART . editor
Date Deposited: 01 May 2019 14:29
Last Modified: 01 May 2019 14:29
URI: http://eprints.kaums.ac.ir/id/eprint/3661

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