Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: A randomized, double-blind, placebo-controlled trial

Asemi, Z. and Karamali, M. and Jamilian, M. and Foroozanfard, F. and Bahmani, F. and Heidarzadeh, Z. and Benisi-Kohansal, S. and Surkan, P.J. and Esmaillzadeh, A. (2015) Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: A randomized, double-blind, placebo-controlled trial. American Journal of Clinical Nutrition, 102 (1). pp. 222-229.

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Abstract

Background: To our knowledge, prior research has not examined the effects of magnesium supplementation on metabolic status and pregnancy outcomes in maternal-child dyads affected by gestational diabetes (GDM). Objective: This study was designed to assess the effects of magnesium supplementation on metabolic status and pregnancy outcomes in magnesium-deficient pregnant women with GDM. Design: A randomized, double-blind, placebo-controlled clinical trial was performed in 70 women with GDM. Patients were randomly assigned to receive either 250 mg magnesium oxide (n = 35) or a placebo (n = 35) for 6 wk. Fasting blood samples were taken at baseline and after a 6-wk intervention. Results: The change in serum magnesium concentration was greater in women consuming magnesium than in the placebo group (+0.06 ± 0.3 vs. -0.1 ± 0.3 mg/dL, P = 0.02). However, after controlling for baseline magnesium concentrations, the changes in serum magnesium concentrations were not significantly different between the groups. Changes in fasting plasma glucose (-9.7 ± 10.1 vs. +1.8 ± 8.1 mg/dL, P < 0.001), serum insulin concentration (-2.1 ± 6.5 vs. +5.7 ± 10.7 μIU/mL, P = 0.001), homeostasis model of assessment-estimated insulin resistance (-0.5 ± 1.3 vs. +1.4 ± 2.3, P < 0.001), homeostasis model of assessment- estimated β-cell function (-4.0 ± 28.7 vs. +22.0 ± 43.8, P = 0.006), and the quantitative insulin sensitivity check index (+0.004 ± 0.021 vs. -0.012 ± 0.015, P = 0.005) in supplemented women were significantly different from those in women in the placebo group. Changes in serum triglycerides (+2.1 ± 63.0 vs. +38.9 ± 37.5 mg/dL, P = 0.005), high sensitivity C-reactive protein (-432.8 ± -521.0 vs. +783.2 ± -470.1 ng/mL, P = 0.03), and plasma malondialdehyde concentrations (20.5 ± 1.6 vs. +0.3 ± 1.2 μmol/L, P = 0.01) were significantly different between the supplemented women and placebo group. Magnesium supplementation resulted in a lower incidence of newborn hyperbilirubinemia (8.8 vs. 29.4, P = 0.03) and newborn hospitalization (5.9 vs. 26.5, P = 0.02). Conclusion: Magnesium supplementation among women with GDM had beneficial effects on metabolic status and pregnancy outcomes. © 2015 American Society for Nutrition.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: bilirubin; C reactive protein; glucose; glutathione; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; magnesium; magnesium oxide; malonaldehyde; placebo; thiobarbituric acid reactive substance; triacylglycerol; very low density lipoprotein cholesterol; C reactive protein; glucose blood level; insulin; magnesium, adult; Apgar score; Article; bilirubin blood level; body mass; cesarean section; cholesterol blood level; controlled study; diet supplementation; dietary intake; double blind procedure; female; glucose blood level; hospitalization; human; hydramnios; hypoglycemia; insulin blood level; insulin resistance; insulin treatment; magnesium blood level; major clinical study; metabolism; neonatal hyperbilirubinemia; newborn; pancreas islet beta cell; physical activity; pregnancy diabetes mellitus; pregnancy outcome; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; triacylglycerol blood level; blood; Diabetes, Gestational; diet restriction; diet supplementation; drug effects; magnesium deficiency; metabolism; oxidative stress; pregnancy, Adult; Blood Glucose; Body Mass Index; C-Reactive Protein; Diabetes, Gestational; Dietary Supplements; Double-Blind Method; Fasting; Female; Humans; Insulin; Insulin Resistance; Magnesium; Magnesium Deficiency; Oxidative Stress; Pregnancy; Pregnancy Outcome
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 17:11
Last Modified: 07 Mar 2017 17:11
URI: http://eprints.kaums.ac.ir/id/eprint/366

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