Distribution of IL-28B genotypes in patients with hepatitis C and healthy individuals in Jahrom city

Mousavi Nasab, S.D. and Baharlou, R. and Piroozmand, A. and Toghyani, H. and Shadmand, E. and Fazel, H. and Sadeghi, K. and Ali-Hashemi, S.M. and Shokouh, M.R. and Gheshlaghi, A. and Ahmadi, N.A. and Vasmehjani, A.A. (2015) Distribution of IL-28B genotypes in patients with hepatitis C and healthy individuals in Jahrom city. Gastroenterology and Hepatology from Bed to Bench, 8 (4). pp. 278-287.

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Abstract

Aim: The purpose of this study was to compare the distribution of interleukin (IL)-28B genotypes between Iranian healthy individuals and patients with chronic hepatitis C based on the genotype. Background: Polymorphisms in the region of IL-28B gene have been identified as the strongest genetic pretreatment predictor of sustained virological response (SVR) in hepatitis C infection. Patients and methods: In this study, 147 patients with chronic hepatitis C and 80 healthy individuals were included. The IL-28B rs12979860 and rs8099917 polymorphisms were genotyped by PCR-RFLP method and the frequency of IL-28B polymorphisms with respect to HCV genotypes was also determined. Results: The frequencies of rs12979860 TT, CC and CT genotypes in the chronic hepatitis C patients and healthy individuals were as follows: 10.8 vs. 11.3, 38.7 vs. 46.2 and 50.3 vs. 42.5. Also, the frequencies of rs8099917 TT, GG and GT genotypes in the chronic hepatitis C patients was 61.9, 6.1 and 32 and in controls was 47.5, 11.2 and 41.3. The differences in the distribution of rs12979860 genotypes and alleles between HCV genotype 1 and HCV genotype 3a infected patients were statistically significant. Conclusion: The rs12979860 C allele is the favorable allele for the spontaneous clearance of HCV. It seems that the impact of IL-28B polymorphism on the spontaneous clearance of HCV genotype 3 is more prominent than HCV genotype 1, which results in the observation of higher rs12979860 C allele frequency in chronic hepatitis C patients with HCV genotype 3 than HCV genotype 1. © 2015 RIGLD, Research Institute for Gastroenterology and Liver Diseases.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: interleukin 28B, acute hepatitis C; adult; Article; chronic hepatitis C; controlled study; cross-sectional study; female; gene frequency; gene identification; genetic association; genetic polymorphism; genotype; hepatitis C; Hepatitis C virus genotype 1; Hepatitis C virus genotype 3; human; IL 28B gene; Iran; major clinical study; male; polymerase chain reaction; restriction fragment length polymorphism; viral clearance
Subjects: Immunology and Microbiology
Divisions: Faculty of Medicine > Basic Sciences > Department of Microbiology & Immunology
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 19:02
Last Modified: 12 Mar 2017 14:55
URI: http://eprints.kaums.ac.ir/id/eprint/365

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