Neuroendocrine carcinoma of the tongue

Esmati, E. and Babaei, M. and Matini, A. and Ashtiani, M.S.M. and Hamed, E.A. and Nosrati, H. and Razi, F. and Ganjalikhani, M. (2015) Neuroendocrine carcinoma of the tongue. Journal of Cancer Research and Therapeutics, 11 (3). p. 659.

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Neuroendocrine carcinoma usually originates from lung. Few data exist in the literature regarding neuroendocrine carcinoma of the tongue. Patient data including history, surgical procedure, histology, and radiology investigations were collected and summarized. A 40-year-old woman was referred after partial glossectomy. Squamous mucosa with neoplasm and cells with round nuclei and light cytoplasm was reported in the tongue biopsy. Immunohistochemistry (IHC) staining was positive for cytokeratin, neuron specific enolase, synaptophysin and chromogranin and negative for leukocyte common antigen. This case showed a high proliferative activity (Ki-67 labeling index were 60). These IHC findings were in favor of poorly differentiated neuroendocrine carcinoma. After surgery, she received chemotherapy and chemoradiation. The diagnosis of neuroendocrine tumors in the present case is based on immunohistochemical markers and cellular shapes. Postoperative chemoradiotherapy is a critical element of therapy for head and neck high-grade neuroendocrine carcinomas, our patient received this treatment after surgery.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: CD45 antigen; chromogranin; cisplatin; cytokeratin; etoposide; neuron specific enolase; synaptophysin; antineoplastic agent, adult; Article; cancer combination chemotherapy; cancer radiotherapy; cancer surgery; case report; chemoradiotherapy; female; glossectomy; human; human tissue; immunohistochemistry; labeling index; multiple cycle treatment; neuroendocrine tumor; oral biopsy; partial glossectomy; patient referral; perineural invasion; postoperative care; tongue carcinoma; tongue neuroendocrine carcinoma; tumor biopsy; Carcinoma, Neuroendocrine; mouth mucosa; pathology; radiography; tongue; Tongue Neoplasms; treatment outcome, Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Neuroendocrine; Chemoradiotherapy; Female; Humans; Mouth Mucosa; Tongue; Tongue Neoplasms; Treatment Outcome
Subjects: Pathology
Divisions: Faculty of Medicine > Basic Sciences > Department of Pathology& Histology
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 18:57
Last Modified: 07 Mar 2017 18:57

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