Banafshe, H.R. and Hajhashemi, V. and Minaiyan, M. and Mesdaghinia, A. and Abed, A. (2015) Antinociceptive effects of maprotiline in a rat model of peripheral neuropathic pain: Possible involvement of opioid system. Iranian Journal of Basic Medical Sciences, 18 (8). pp. 752-757.
Full text not available from this repository.Abstract
Objective(s): Neuropathic pain remains a clinical problem and is poorly relieved by conventional analgesics. This study was designed to determine whether maprotiline administration was effective in alleviating symptoms of neuropathic pain and whether the antinociceptive effect of maprotiline mediated through the opioid system. Materials and Methods: Neuropathic pain was induced by chronic constriction injury (CCI) of the sciatic nerve in rats, which resulted in thermal hyperalgesia, and mechanical and cold allodynia. Maprotiline (10, 20 and 40 mg/kg, IP) was administered on the 7th and 14th days after surgery. To study the role of the opioid system in the antinociceptive effects of maprotiline, maprotiline (20 mg/kg, IP) was administered in combination with naloxone (1 mg/kg, SC) on the 7th post-surgery day. Behavioral tests were done at 45 min after drug injections on the 7th and 14th days after surgery. Results: Systemic administration of maprotiline blocked heat hyperalgesia, cold allodynia and reduced mechanical allodynia. Also antihyperalgesic effect of maprotiline was reversed by pretreatment with naloxone. Conclusion: Our results suggest that maprotiline can be considered a potential therapeutic for the treatment of neuropathic pain, and the opioid system may be involved in the antihyperalgesic effects of maprotiline. Copyright 2015, Mashhad University of Medical Sciences , All Rights Reserved.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 1 |
| Uncontrolled Keywords: | maprotiline; naloxone; opiate receptor, acetone spray test; allodynia; animal experiment; animal model; antinociception; Article; cold allodynia; experimental behavioral test; hyperalgesia; male; mechanical allodynia; neuropathic pain; nonhuman; plantar test; rat; sciatic nerve injury; thermal hyperalgesia |
| Subjects: | Pharmacology, Toxicology and Pharmaceutics |
| Divisions: | Faculty of Medicine > Basic Sciences > Department of Pharmacology |
| Depositing User: | editor . 2 |
| Date Deposited: | 07 Mar 2017 19:56 |
| Last Modified: | 07 Mar 2017 19:56 |
| URI: | http://eprints.kaums.ac.ir/id/eprint/347 |
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