Chromium supplementation and the effects on metabolic status in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial

Jamilian, M. and Asemi, Z. (2015) Chromium supplementation and the effects on metabolic status in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Annals of Nutrition and Metabolism, 67 (1). pp. 42-48.

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Abstract

Background: The aim of the present study was to evaluate the beneficial effects of chromium intake on markers of insulin metabolism and lipid profiles in women with polycystic ovary syndrome (PCOS). Methods: In a prospective, randomized, double-blind, placebo-controlled trial, 64 women with PCOS were randomized to receive 200 μg chromium picolinate supplements (n = 32) or placebo (n = 32) for 8 weeks. Fasting blood samples were obtained at baseline and 8 weeks after the intervention to quantify markers of insulin metabolism and lipid concentrations. Results: Chromium supplementation in women with PCOS resulted in significant decreases in serum insulin levels (-3.6 ± 7.4 vs. +3.6 ± 6.2 μIU/ml, p < 0.001), homeostasis model of assessmentinsulin resistance (HOMA-IR; -0.8 ± 1.6 vs. +0.9 ± 1.5, p < 0.001), homeostatic model assessment-beta cell function (HOMA-B; -15.5 ± 32.3 vs. +13.6 ± 23.1, p < 0.001), and a significant increase in quantitative insulin sensitivity check index (QUICKI) score (+0.02 ± 0.03 vs. -0.008 ± 0.02, p = 0.001) compared with the placebo. In addition, a trend toward a significant effect of chromium supplementation on decreasing serum triglycerides (-12.4 ± 74.4 vs. +15.2 ± 32.4 mg/dl, p = 0.05), very low-density lipoprotein-cholesterol (-2.5 ± 14.9 vs. +3.0 ± 6.5 mg/dl, p = 0.05), and cholesterol concentrations (-8.6 ± 21.9 vs. +0.7 ± 22.4 mg/dl, p = 0.09) was seen. Conclusions: Eight weeks of chromium supplementation among PCOS women had favorable effects on markers of insulin metabolism. © 2015 S. Karger AG, Basel.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: chromium; placebo; triacylglycerol; very low density lipoprotein cholesterol; cholesterol; insulin; iron chelating agent; picolinic acid; picolinic acid derivative; triacylglycerol; very low density lipoprotein cholesterol, adult; Article; blood sampling; cell function; controlled study; diet restriction; female; human; insulin blood level; insulin metabolism; lifestyle modification; major clinical study; male; ovary polycystic disease; pancreas islet beta cell; priority journal; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; supplementation; triacylglycerol blood level; vitamin supplementation; blood; dietary supplement; double blind procedure; homeostasis; insulin resistance; physiology; Polycystic Ovary Syndrome; prospective study; young adult, Adult; Cholesterol; Cholesterol, VLDL; Dietary Supplements; Double-Blind Method; Fasting; Female; Homeostasis; Humans; Insulin; Insulin Resistance; Insulin-Secreting Cells; Iron Chelating Agents; Picolinic Acids; Polycystic Ovary Syndrome; Prospective Studies; Triglycerides; Young Adult
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 17:12
Last Modified: 07 Mar 2017 17:12
URI: http://eprints.kaums.ac.ir/id/eprint/344

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