The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress among Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Akbari, M. and Ostadmohammadi, V. and Lankarani, K.B. and Tabrizi, R. and Kolahdooz, F. and Heydari, S.T. and Kavari, S.H. and Mirhosseini, N. and Mafi, A. and Dastorani, M. and Asemi, Z. (2018) The Effects of Vitamin D Supplementation on Biomarkers of Inflammation and Oxidative Stress among Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Hormone and Metabolic Research, 50 (4). pp. 271-279.

Full text not available from this repository.
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....
DOI: UNSPECIFIED

Abstract

Abstract The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of vitamin D supplementation on biomarkers of inflammation and oxidative stress among women with polycystic ovary syndrome (PCOS). Cochrane library, Embase, PubMed, and Web of Science database were searched to identify related randomized-controlled articles (RCTs) published up to November 2017. Two researchers assessed study eligibility, extracted data, and evaluated risk of bias of included RCTs, independently. To check heterogeneity Q-test and I2 statistics were used. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as summary effect size. Seven RCTs were included into our meta-analysis. The findings showed that vitamin D supplementation in women with PCOS significantly decreased high-sensitivity C-reactive protein (hs-CRP) (SMD −1.03; 95% CI, −1.58, −0.49; p <0.001) and malondialdehyde (MDA) (SMD −1.64, 95% CI −2.26 to −1.02, p <0.001), and significantly increased total antioxidant capacity (TAC) levels (SMD 0.86, 95% CI 0.08 to 1.64, p=0.03). Vitamin D supplementation had no significant effect on nitric oxide (NO) (SMD 0.11, 95% CI −0.44 to 0.66, p=0.69) and total glutathione (GSH) levels (SMD 0.54, 95% CI −0.20 to 1.28, p=0.15). Overall, the current meta-analysis demonstrated that vitamin D supplementation to women with PCOS resulted in an improvement in hs-CRP, MDA and TAC, but did not affect NO and GSH levels. Key words: vitamin D supplementation - inflammation - oxidative stress - polycystic ovary syndrome - meta-analysis

Item Type: Article
Additional Information: cited By 1
Subjects: Endocrinology Metabolism
Midwifery
Divisions: Faculty of Nursing & Midwifery > Department of Midwifery
Depositing User: ART . editor
Date Deposited: 17 Feb 2019 09:44
Last Modified: 17 Feb 2019 09:44
URI: http://eprints.kaums.ac.ir/id/eprint/3418

Actions (login required)

View Item View Item