Probiotic plus low-calorie diet increase gene expression of Toll-like receptor 2 and FOXP3 in overweight and obese participants

Yazdani, B. and Shidfar, F. and Salehi, E. and Baghbani-arani, F. and Razmpoosh, E. and Asemi, Z. and Cheshmazar, E. and Zarrati, M. (2018) Probiotic plus low-calorie diet increase gene expression of Toll-like receptor 2 and FOXP3 in overweight and obese participants. Journal of Functional Foods, 43. pp. 180-185.

Full text not available from this repository.
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....
DOI: UNSPECIFIED

Abstract

Abstract We evaluated the effects of probiotic supplementation with a low-calorie diet on the gene expression of mediators of the immune system among overweight and obese individuals; participants were randomly divided into three groups of 25 each: group 1 consumed conventional yogurt with a low-calorie diet (CLCD); group 2 consumed probiotic yogurt with a low-calorie diet (PLCD) and group 3 consumed probiotic yogurt without a low-calorie diet (PWLCD) for 8 weeks. Probiotic yogurt contained Lactobacillus acidophilus LA5, Lactobacillus casei DN001, Bifidobacterium lactis Bb12 and Streptococcus thermophiles (108 CFU/mL each). Quantitative results of RT-PCR demonstrated that there was an increase in the gene expression of toll like receptor 2(TLR2) in PLCD group compared to CLCD and PWLCD groups (2.7 ± 2.8 vs. 0.9 ± 0.8, 1.9 ± 1.6, respectively, P = 0.001) as well as an increase in FOXP3 gene in PLCD group compared to the other groups (11.2 ± 6.7 vs. 6 ± 2.5, 6.3 ± 1.9, respectively, P < 0.001). Our study demonstrated that the 8-week consumption of PLCD among overweight and obese individuals resulted in a significant up-regulation in the expression of the TLR2. Keywords: Probiotic Obesity Gene expression Toll like receptor 2 Nuclear factor kappa B

Item Type: Article
Additional Information: cited By 0
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 17 Feb 2019 09:38
Last Modified: 17 Feb 2019 09:38
URI: http://eprints.kaums.ac.ir/id/eprint/3417

Actions (login required)

View Item View Item