Use of ferric sulfate to control hepatic bleeding

Nouri, S. and Sharif, M.R. (2015) Use of ferric sulfate to control hepatic bleeding. Trauma Monthly, 20 (1). pp. 47-51.

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Background: Controlling parenchymal hemorrhage, especially in liver parenchyma, despite all the progress in surgical science, is still one of the challenges surgeons face. Therefore, search for an effective method to control hepatic bleeding is an important research priority. Objectives: This study attempted to determine the haemostatic effect of ferric sulfate and compare it with the standard method (suturing technique). Materials and Methods: In this animal model study, 60 male Wistar rats were used. An incision (2 cm in length and 1/2 cm in depth) was made on each rat's liver and the hemostasis time was measured using ferric sulfate with different concentrations (5, 10, 15, 25, and 50) and then using simple suturing. The liver tissue was assessed for pathological changes. Results: In all the groups, complete hemostasis occurred. Hemostasis times of different concentrations of ferric sulfate were significantly less than those of the control group (P < 0.001). Conclusions: Ferric sulfate was effective in controlling hepatic bleeding in rats. Copyright © 2015, Trauma Monthly.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: cefalotin; ferric sulfate, animal cell; animal experiment; animal model; animal tissue; aqueous solution; Article; controlled study; hemostasis; histopathology; incision; intermethod comparison; liver; liver hemorrhage; liver parenchyma; male; microscopy; nonhuman; rat; suturing method
Subjects: Physiology
Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Clinical Sciences > Department of Pediatrics
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 19:53
Last Modified: 07 Mar 2017 19:53

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