Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies

Mirzaei, H. and Shakeri, A. and Rashidi, B. and Jalili, A. and Banikazemi, Z. and Sahebkar, A. (2017) Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies. Biomedicine and Pharmacotherapy, 85. pp. 102-112.

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Abstract

Curcumin, a hydrophobic polyphenol, is the principal constituent extracted from dried rhizomes of Curcuma longa L. (turmeric). Curcumin is known as a strong anti-oxidant and anti-inflammatory agent that has different pharmacological effects. In addition, several studies have demonstrated that curcumin is safe even at dosages as high as 8 g per day; however, instability at physiological pH, low solubility in water and rapid metabolism results in a low oral bioavailability of curcumin. The phytosomal formulation of curcumin (a complex of curcumin with phosphatidylcholine) has been shown to improve curcumin bioavailability. Existence of phospholipids in phytosomes leads to specific physicochemical properties such as amphiphilic nature that allows dispersion in both hydrophilic and lipophilic media. The efficacy and safety of curcumin phytosomes have been shown against several human diseases including cancer, osteoarthritis, diabetic microangiopathy and retinopathy, and inflammatory diseases. This review focuses on the pharmacokinetics as well as pharmacological and clinical effects of phytosomal curcumin. © 2016

Item Type: Article
Additional Information: cited By 0
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Biochemistry
Depositing User: editor . 2
Date Deposited: 26 Feb 2017 11:22
Last Modified: 11 Mar 2017 13:41
URI: http://eprints.kaums.ac.ir/id/eprint/34

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