Investigating the effect of zinc chloride on control of liver hemorrhage; an animal model study

Nouri, S. and Sharif, M.R. (2015) Investigating the effect of zinc chloride on control of liver hemorrhage; an animal model study. Journal of Isfahan Medical School, 32 (308). pp. 1845-1854.

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Abstract

Background: The control of parenchymal hemorrhage, especially in liver parenchyma, despite surgical science progresses, is still one of the challenges surgeons face saving the patients� lives; and there is a research challenge between the researchers in this field to introduce a more effective method. This study aimed to determine the hemostatic effect of zinc chloride on controlling the bleeding from liver parenchymal tissue. Methods: In this animal model study, 60 male Wistar rats were used. An incision with length of 2 and depth of 0.5 cm was made on each mouse�s liver and the hemostasis time was measured using zinc chloride different concentrations (5, 10, 15, 25, and 50) and the control method (i.e. control of bleeding via suturing). Findings: In all the groups, complete hemostasis occurred; the hemostasis times of zinc chloride concentration groups were significantly less than that of the control group (P < 0.001). At concentrations of 5, 10 and 15 of zinc chloride and suture group, pathological grade one was seen. In addition, in the 25 and 50 zinc chloride groups, pathological grade two was the most common grade (70 and 80, respectively). Conclusion: Zinc chloride is an effective hemostatic agent in controlling liver parenchymal tissue hemorrhage in an animal model; it can control the liver bleeding, also at the lowest concentration (5). © 2015, Isfahan University of Medical Sciences(IUMS). All rights reserved.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: zinc chloride, animal model; animal tissue; Article; controlled study; drug effect; hemostasis; liver hemorrhage; male; nonhuman; rat
Subjects: Physiology
Divisions: Faculty of Medicine > Clinical Sciences > Department of Pediatrics
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 19:23
Last Modified: 07 Mar 2017 19:23
URI: http://eprints.kaums.ac.ir/id/eprint/339

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