The effects of folate supplementation on lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials

Tabrizi, R. and Lankarani, K.B. and Akbari, M. and Naghibzadeh-Tahami, A. and Alizadeh, H. and Honarvar, B. and Sharifi, N. and Mazoochi, M. and Ostadmohammadi, V. and Fatholahpour, A. and Asemi, Z. (2018) The effects of folate supplementation on lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 12 (3). pp. 423-430.

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Abstract

Abstract Background and objective Although several studies have assessed the effect of folate supplementation on lipid profiles among patients with metabolic diseases, findings are inconsistent. This review of randomized controlled trials (RCTs) was conducted to summarize the evidence on the effects of folate supplementation on lipid profiles among patients with metabolic diseases. Methods Randomized-controlled trials (RCTs) published in PubMed, EMBASE, Web of Science and Cochrane Library databases up to until 20 August 2017 were searched. Two review authors independently assessed study eligibility, extracted data, and evaluated risk of bias of included studies. Heterogeneity was measured with a Q-test and with I2 statistics. Data were pooled by using the fix or random-effect model based on the heterogeneity test results and expressed as standardized mean difference (SMD) with 95% confidence interval (CI). Results A total of thirteen randomized controlled trials were included. Folate supplementation did not affect systolic blood pressure (SMD −0.87; 95% CI, −1.83, 0.09) and diastolic blood pressure (SMD −0.59; 95% CI, −1.55, 0.37), and lipid profiles including triglycerides (SMD 0.10; 95% CI, −0.42, 0.63), total- (SMD 0.06; 95% CI, −0.31, 0.43), HDL- (SMD 0.04; 95% CI, −0.36, 0.44), VLDL- (SMD 0.08; 95% CI, −0.24, 0.41), and LDL-cholesterol (SMD −0.14; 95% CI, −0.55, 0.28). Conclusions Folate supplementation did not affect blood pressures and lipid profiles among patients with metabolic diseases. Additional prospective studies regarding the impact of folate supplementation on blood pressures and lipid profiles in patients with metabolic diseases are necessary. Keywords Folate Lipid profiles Metabolic diseases Meta-analysis

Item Type: Article
Additional Information: cited By 0
Subjects: Nutrition
Endocrinology Metabolism
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 04 Mar 2019 10:35
Last Modified: 04 Mar 2019 10:35
URI: http://eprints.kaums.ac.ir/id/eprint/3389

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