Stem Cell Tracing Through MR Molecular Imaging

Yahyapour, R. and Farhood, B. and Graily, G. and Rezaeyan, A. and Rezapoor, S. and Abdollahi, H. and Cheki, M. and Amini, P. and Fallah, H. and Najafi, M. and Motevaseli, E. (2018) Stem Cell Tracing Through MR Molecular Imaging. Tissue Engineering and Regenerative Medicine, 15 (3). pp. 249-261.

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Abstract Stem cell therapy opens a new window in medicine to overcome several diseases that remain incurable. It appears such diseases as cardiovascular disorders, brain injury, multiple sclerosis, urinary system diseases, cartilage lesions and diabetes are curable with stem cell transplantation. However, some questions related to stem cell therapy have remained unanswered. Stem cell imaging allows approval of appropriated strategies such as selection of the type and dose of stem cell, and also mode of cell delivery before being tested in clinical trials. MRI as a non-invasive imaging modality provides proper conditions for this aim. So far, different contrast agents such as superparamagnetic or paramagnetic nanoparticles, ultrasmall superparamagnetic nanoparticles, fluorine, gadolinium and some types of reporter genes have been used for imaging of stem cells. The core subject of these studies is to investigate the survival and differentiation of stem cells, contrast agent’s toxicity and long term following of transplanted cells. The promising results of in vivo and some clinical trial studies may raise hope for clinical stem cells imaging with MRI. Keywords: Stem cell, MRI, Molecular imaging, Regenerative medicine, Cell therapy

Item Type: Article
Additional Information: cited By 0
Subjects: Medicine
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Clinical Sciences > Department of Radiology
Depositing User: ART . editor
Date Deposited: 02 Mar 2019 11:04
Last Modified: 02 Mar 2019 11:04

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