Efficacy and safety of aluminum chloride in controlling external hemorrhage: An animal model study

Nouri, S. and Sharif, M.R. and Panahi, Y. and Ghanei, M. and Jamali, B. (2015) Efficacy and safety of aluminum chloride in controlling external hemorrhage: An animal model study. Iranian Red Crescent Medical Journal, 17 (3). pp. 1-5.

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Background: Despite all the progress in surgical science, bleeding caused by traffic accidents is still one of the challenges surgeons face in saving patients� lives. Therefore, introducing an effective method to control external bleeding is an important research priority. Objectives: This study aimed to compare the haemostatic effect of aluminum chloride versus simple suturing in controlling external bleeding. Materials and Methods: This experimental study was conducted in Kashan, Iran. In this study, 60 male Wistar rats were randomly allocated into six groups. An incision, two centimeters (cm) long and half a cm deep, was made on each rat�s shaved back skin and the haemostatic time was measured once using aluminum chloride with different concentrations (5, 10, 15, 25, and 50) and then using the control method (controlling hemorrhage by simple suturing). The skin tissue was assessed for pathological changes. Results: The haemostatic time of aluminum chloride 50, 25, 15, 10 and 5 were 8.20 ± 0.919, 14.10 ± 1.37, 21.20 ± 1.31, 30.80 ± 1.68 and 42.00 ± 4.19 seconds, respectively. Also, the mean homeostasis time in the control group (suture) was 84.00 ± 4.05 seconds. The haemostatic times of different concentrations of aluminum chloride were significantly less than that of the control group. There was a statistically significant difference between every two haemostatic time. The pathologic examination showed the highest frequency of low-grade inflammation based on the defined pathological grading. Conclusions: The aluminum chloride method needs less time to control external hemorrhage compared to the control method (controlling external hemorrhage by simple suturing). Aluminum chloride is an effective agent in controlling external hemorrhage in An animal model. © 2015, Iranian Red Crescent Medical Journal.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: aluminum chloride; cefalotin, animal experiment; animal model; animal tissue; Article; bleeding; controlled study; drug efficacy; drug safety; hemostasis; inflammation; male; nonhuman; rat; suturing method
Subjects: Physiology
Pharmacology, Toxicology and Pharmaceutics
Divisions: Faculty of Medicine > Clinical Sciences > Department of Pediatrics
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 19:36
Last Modified: 07 Mar 2017 19:36
URI: http://eprints.kaums.ac.ir/id/eprint/337

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