Prediction of response to treatment in children with epilepsy

Ghofrani, M. and Nasehi, M.M. and Saket, S. and Mollamohammadi, M. and Taghdiri, M.M. and Karimzadeh, P. and Tonekaboni, S.H. and Javadzadeh, M. and Jafari, N. and Zavehzad, A. and Hasanvand Amouzadeh, M. and Beshrat, M. and Babaei, M. (2018) Prediction of response to treatment in children with epilepsy. Iranian Journal of Child Neurology, 12 (3). pp. 94-100.

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Abstract Objective: This study was conducted to predict the response to treatment in patients treated with anti-epilepsy drugs. Material and Methods: This analytical questionnaire-based study was conducted in 2014 among 128 patients with epilepsy admitted to Mofid Children's Hospital, Tehran, Iran. The inclusion criteria were children 2 months to 12 yr of age with epilepsy and patients who experienced fever and seizure attacks at least once were excluded from the study. Patients were followed up for 6 months and the response to their treatment was recorded. The good response to treatment was defined as the absence of seizure with two drugs during follow up. Results: Seventy-two patients (56.3%) were boys. The age of the first seizure was under 2 yr old in 90 patients (70.3%). History of febrile convulsion, family history of epilepsy and history of asphyxia was found in 16 (12.5%), 41 (32%), and 27 (21.1%) patients, respectively. Seizure etiology was idiopathic in 90 patients (70.3%), and the number of seizures was 1-2 in 36 patients (28.1%). Overall, 57 patients (44.5%) had cerebral lesion according to CT scan or MRI, and EEG was abnormal in 101 patients (78.9%). In 6-month follow-up, 40 patients (31.3%) responded well to the treatment and 88 patients (68.8%) responded poorly to the treatment. History of asphyxia (OR = 6.82), neonatal jaundice (OR = 2.81) and abnormal EEG (OR = 0.19) were effective factors in response to treatment. Conclusion: Abnormal EEG is an effective factor in treatment response in the children studied. Key Words: Pediatric, Anti-seizure drug, Response to treatment, Children, Epilepsy

Item Type: Article
Additional Information: cited By 0
Subjects: Psychology
Divisions: Faculty of Medicine > Clinical Sciences > Department of Psychiatry
Depositing User: ART . editor
Date Deposited: 04 Mar 2019 15:06
Last Modified: 04 Mar 2019 15:06

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