Clinical signs and symptoms and laboratory findings of methadone poisoning in children

Sharif, M.R. and Nouri, S. (2015) Clinical signs and symptoms and laboratory findings of methadone poisoning in children. Iranian Journal of Pediatrics, 25 (1).

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Background: Poisoning accounts for about 7 of all accidents in children under 5 years and is implicated in over 5 of all childhood deaths in developing countries. Objectives: Due to the potential risks of methadone poisoning in children and increased cases of methadone poisoning among Iranian children, this study was conducted to investigate the clinical signs and symptoms and laboratory findings of methadone toxicity in children. Patients and Methods: The present retrospective, descriptive, cross-sectional study describes the clinical symptoms and signs and laboratory findings of methadone poisoning in children under 12 years old in Shahid Beheshti Hospital, Kashan, during the years 2009 to 2013. Results: Of 58 patients, 33 (56.9) were male and 25 (43.1) female (P = 0.294). The mean age of patients was 5.2 ± 1.0 years. All the cases of poisoning happened with methadone syrup, due to unsafe keeping of methadone in mineral water bottles and containers of other drugs. Signs and symptoms included drowsiness (91.4), miosis (75.9), vomiting (69.0), ineffective breathing (any kind of breathing problem except apnea) (62.1), apnea (53.4), cyanosis (43.1), seizure (8.6), ataxia (6.9) and delirium (3.4). Conclusions: Keeping methadone in appropriate containers and warning methadone consumers about the dangerous side effects of its consumption and the symptoms of methadone poisoning in children may minimize the occurrence of this form of poisoning and its complications in children. © 2015, Growth & Development Research Center.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: methadone; mineral water; naloxone, apnea; Article; aspiration pneumonia; ataxia; brain death; brain hemorrhage; breathing disorder; child; clinical feature; container; cross-sectional study; cyanosis; delirium; drowsiness; female; hospitalization; human; intoxication; Iran; Iranian people; laboratory test; major clinical study; male; methadone poisoning; methadone poisoning; miosis; pneumonia; preschool child; retrospective study; seizure; symptom; treatment outcome; vomiting
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Pediatrics
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 19:35
Last Modified: 07 Mar 2017 19:35

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