The effect of zinc and vitamin E cosupplementation on metabolic status and its related gene expression in patients with gestational diabetes

Ostadmohammadi, V. and Samimi, M. and Mobini, M. and Zarezade Mehrizi, M. and Aghadavod, E. and Chamani, M. and Dastorani, M. and Asemi, Z. (2018) The effect of zinc and vitamin E cosupplementation on metabolic status and its related gene expression in patients with gestational diabetes. Journal of Maternal-Fetal and Neonatal Medicine. pp. 1-8.

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Abstract

Abstract Objective: The aim of this study was to determine the effects of zinc and vitamin E cosupplementation on metabolic status and gene expression related to insulin and lipid metabolism in women with gestational diabetes mellitus (GDM). Methods: Fifty-four women, in the age range of 18–40 years, diagnosed with GDM were recruited for this randomized, double-blinded, placebo-controlled trial. Subjects were randomly allocated into two intervention groups to either taking 233 mg/day Zinc Gluconate plus 400-IU/day vitamin E supplements or placebo (n = 27 each group) for 6 weeks. Gene expression related to insulin and lipid metabolism was evaluated in peripheral blood mononuclear cells (PBMCs) of women with GDM using RT-PCR method. Results: Participants who received zinc plus vitamin E supplements had significantly lower serum insulin levels (β = −3.81; 95% CI, −5.90, −1.72; p = .001), homeostasis model of assessment-insulin resistance (β = −0.96; 95% CI, −1.54, −0.38; p = .002), serum total-cholesterol (β = −8.56; 95% CI, −16.69, −0.43; p = .03) and low density lipoprotein-cholesterol (LDL)-cholesterol (β = −8.72; 95% CI, −15.27, −2.16; p = .01), and higher quantitative insulin sensitivity check index (β = 0.01; 95% CI, 0.005, 0.02; p = .007) compared with the placebo. Moreover, zinc and vitamin E cosupplementation upregulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-γ; p = .03) and low-density lipoprotein receptor (LDLR; p = .04) compared with the placebo. Though, zinc and vitamin E combination did not affect other metabolic parameters. Conclusions: Overall, zinc and vitamin E cosupplementation for 6 weeks in women with GDM significantly improved insulin metabolism, lipid profile, and the gene expression levels of PPAR-γ and LDLR. Keywords: Gene expression, gestational diabetes, insulin, lipid, supplementation

Item Type: Article
Additional Information: cited By 0; Article in Press
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 04 Mar 2019 10:43
Last Modified: 04 Mar 2019 10:43
URI: http://eprints.kaums.ac.ir/id/eprint/3357

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