The effects of omega-3 and vitamin E co-supplementation on parameters of mental health and gene expression related to insulin and inflammation in subjects with polycystic ovary syndrome

Jamilian, M. and Shojaei, A. and Samimi, M. and Afshar Ebrahimi, F. and Aghadavod, E. and Karamali, M. and Taghizadeh, M. and Jamilian, H. and Alaeinasab, S. and Jafarnejad, S. and Asemi, Z. (2018) The effects of omega-3 and vitamin E co-supplementation on parameters of mental health and gene expression related to insulin and inflammation in subjects with polycystic ovary syndrome. Journal of Affective Disorders, 229. pp. 41-47.

[img] Text
1-s2.0-S0165032717320967-main.pdf

Download (423kB)
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....
DOI: UNSPECIFIED

Abstract

Abstract Objective The aim of this study was to evaluate the effects of omega-3 and vitamin E co-supplementation on parameters of mental health and gene expression related to insulin and inflammation in subjects with polycystic ovary syndrome (PCOS). Methods Forty PCOS women were allocated into two groups and treated with 1000 mg omega-3 fatty acids plus 400 IU vitamin E supplements (n = 20) or placebo (n = 20) per day for 12 weeks. Parameters of mental health were recorded at baseline and after the 12-week intervention. Gene expression related to insulin and inflammation were measured in blood samples of PCOS women. Results After the 12-week intervention, compared with the placebo, omega-3 and vitamin E co-supplementation led to significant improvements in beck depression inventory total score (− 2.2 ± 2.0 vs. − 0.2 ± 1.3, P = 0.001), general health questionnaire scores (− 5.5 ± 4.6 vs. − 1.0 ± 2.3, P < 0.001) and depression anxiety and stress scale scores (− 7.2 ± 5.2 vs. − 1.3 ± 1.3, P < 0.001). Compared with the placebo, omega-3 and vitamin E co-supplementation could up-regulate peroxisome proliferator-activated receptor gamma (PPAR-γ) expression (P = 0.04) in peripheral blood mononuclear cells (PBMC) of PCOS women. In addition, compared with the placebo, omega-3 and vitamin E co-supplementation down-regulated interleukin-8 (IL-8) (P = 0.003) and tumor necrosis factor alpha (TNF-α) expression (P = 0.001) in PBMC of PCOS women. There were no significant difference between-group changes in glucose transporter 1 (GLUT-1), IL-6 and transforming growth factor beta (TGF-β) in PBMC of PCOS women. Conclusion Omega-3 and vitamin E co-supplementation was effective in improving parameters of mental health, and gene expression of PPAR-γ, IL-8 and TNF-α of women with PCOS. Keywords Supplementation Mental health Gene expression Insulin Inflammation Polycystic ovary syndrome

Item Type: Article
Additional Information: cited By 1
Subjects: Nutrition
Midwifery
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Clinical Sciences > Department of , Obstetrics & Gynecology
Depositing User: ART . editor
Date Deposited: 06 Mar 2019 10:09
Last Modified: 06 Mar 2019 10:09
URI: http://eprints.kaums.ac.ir/id/eprint/3286

Actions (login required)

View Item View Item