Effect of melatonin in reducing second-generation antipsychotic metabolic effects: A double blind controlled clinical trial

Agahi, M. and Akasheh, N. and Ahmadvand, A. and Akbari, H. and Izadpanah, F. (2018) Effect of melatonin in reducing second-generation antipsychotic metabolic effects: A double blind controlled clinical trial. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 12 (1). pp. 9-15.


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Introduction The use of second-generation atypical antipsychotics has an increasing role in the development of metabolic syndrome. However, these medications due to metabolic disorders can lead to an increased risk of cardiovascular disease and subsequently mortality as well as reduced adherence to treatment. The main objective of current study was to determine the ability of melatonin to reduce the metabolic effects of second-generation antipsychotics. Methods This double blind controlled clinical trial was conducted on 100 patients aged 18–64 years old were treated with the second-generation antipsychotics for the first time. The patients were divided randomly into two groups of 50. The case group received slow-release melatonin at a dose of 3 mg and the control group was given oral placebo at 8 p.m. Results The findings in melatonin group indicated significantly increase of HDL and decreased fasting blood sugar and systolic blood pressure, as well as had statistically significant increase in waist circumference, weight and BMI compared with placebo group. Conclusion According to the findings, it can be claimed that the addition of melatonin to atypical antipsychotics has led to a reduction in some of the metabolic effects of these drugs. In this study, HDL level was increased, and the mean systolic blood pressure and FBS were decreased in the melatonin group. Considering that these factors are contributing to cardiovascular disease as a leading cause of mortality in psychiatric patients, so the use of melatonin can reduce some of the medical effects of long-term treatment of atypical antipsychotics. © 2017 Diabetes India

Item Type: Article
Additional Information: cited By 0
Subjects: Psychology
Divisions: Faculty of Medicine > Clinical Sciences > Department of Psychiatry
Depositing User: ART . editor
Date Deposited: 24 May 2018 14:30
Last Modified: 24 May 2018 14:30
URI: http://eprints.kaums.ac.ir/id/eprint/3243

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