The effects of fish oil on gene expression in patients with polycystic ovary syndrome

Rahmani, E. and Jamilian, M. and Dadpour, B. and Nezami, Z. and Vahedpoor, Z. and Mahmoodi, S. and Aghadavod, E. and Taghizadeh, M. and Beiki Hassan, A. and Asemi, Z. (2018) The effects of fish oil on gene expression in patients with polycystic ovary syndrome. European Journal of Clinical Investigation, 48 (3).

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Abstract

Abstract Background This study was conducted to determine the effects of fish oil administration on gene expression related to insulin, lipid and inflammation in women with polycystic ovary syndrome (PCOS). Materials and methods This randomized, double‐blind, placebo‐controlled trial was conducted among 40 subjects with PCOS, aged 18‐40 years. Subjects were randomly allocated into two groups to take either 1000 mg omega‐3 fatty acids from fish oil (n = 20) or placebo (n = 20) twice a day for 12 weeks. Gene expression related to insulin, lipid and inflammation was quantified in peripheral blood mononuclear cells (PBMC) of PCOS women with RT‐PCR method. Results Our study demonstrated that after the 12‐week intervention, compared with the placebo, fish oil supplementation upregulated gene expression of peroxisome proliferator‐activated receptor gamma (PPAR‐γ) (P < .001) in PBMC of subjects with PCOS. In addition, compared to the placebo, taking fish oil supplements downregulated gene expression of interleukin‐1 (IL‐1) (P = .02) and interleukin‐8 (IL‐8) (P = .01) in PBMC of subjects with PCOS. We did not observe any significant effect of fish oil supplementation on gene expression of lipoprotein(a) [LP(a)], low‐density lipoprotein receptor (LDLR), glucose transporter 1 (GLUT‐1), tumour necrosis factor alpha (TNF‐α) and transforming growth factor beta (TGF‐β) in PBMC of subjects with PCOS. Conclusions Overall, fish oil supplementation for 12 weeks to subjects with PCOS significantly improved gene expression of PPAR‐γ, IL‐1 and IL‐8, but did not influence gene expression of LP(a), LDLR, GLUT‐1, TNF‐α and TGF‐β.

Item Type: Article
Additional Information: cited By 0
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: ART . editor
Date Deposited: 06 Apr 2019 15:02
Last Modified: 06 Apr 2019 15:02
URI: http://eprints.kaums.ac.ir/id/eprint/3205

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