Effect of adding the herb Achillea millefolium on mouthwash onchemotherapy induced oral mucositis in cancer patients: Adouble-blind randomized controlled trial

Miranzadeh, S. and Adib-Hajbaghery, M. and Soleymanpoor, L. and Ehsani, M. (2015) Effect of adding the herb Achillea millefolium on mouthwash onchemotherapy induced oral mucositis in cancer patients: Adouble-blind randomized controlled trial. European Journal of Oncology Nursing, 19 (3). pp. 207-213.

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DOI: UNSPECIFIED

Abstract

Background: Oral mucositis (OM) is a debilitating side-effect of chemotherapy. It has different complications, including impairment of drinking, eating and even talking, sometimes so severe that physician stops the therapy. Objective: Investigating the effect of Achillea millefolium distillate solution in the treatment of chemotherapy-induced OM. Interventions/methods: In this randomized controlled trial, 56 cancer patients with chemotherapy-induced OM were randomly assigned into control and experimental groups in similar blocks based on the severity of OM. The experimental group gargled 15mL of a mixture of routine solution and distilled A. millefolium 4 times a day for 14 days while the control group gargled 15mL of routine solution. The severity of OM was assessed at three times before, 7 and 14 days after intervention. Data was analyzed using Wilcoxon, Kruskal-Wallis, Mann-Whitney U, Friedman, Chi-square and Fisher's exact tests. Results: The mean severity score of OM was 2.39±0.875 in both groups at start of the study that was changed to 1.07±0.85 and 0.32±0.54 in the intervention group in days 7 and 14 (. p<0.001). However, the severity of OM was increased to 2.75±0.87 and 2.89±0.956 in the control group respectively (. p<0.001). Conclusions: A. millefolium distillate healed OM much more than the routine solution. Therefore, it is suggested to be used in patients with chemotherapy-induced OM.The study was registered in the Iranian Registry of Clinical Trials, Number: IRCT2013092214729N1. © 2014 Elsevier Ltd.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: antineoplastic agent; mouthwash; plant medicinal product, Achillea; adult; aged; chemically induced; comparative study; complication; controlled study; double blind procedure; female; human; male; middle aged; Neoplasms; phytotherapy; randomized controlled trial; stomatitis; treatment outcome, Achillea; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Double-Blind Method; Female; Humans; Male; Middle Aged; Mouthwashes; Neoplasms; Phytotherapy; Plant Preparations; Stomatitis; Treatment Outcome
Subjects: Medicine
Divisions: Faculty of Nursing & Midwifery > Department of Nursing - Medical Surgical
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 17:14
Last Modified: 07 Mar 2017 17:14
URI: http://eprints.kaums.ac.ir/id/eprint/320

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