Evaluation of prevalence pure red cell aplasia due to antibody against erythropoietin in hemodialysis patients

Rahbar, M. and Chitsazian, Z. and Abdoli, F. and Moeini Taba, S.M. and Akbari, H. (2017) Evaluation of prevalence pure red cell aplasia due to antibody against erythropoietin in hemodialysis patients. Journal of Nephropathology, 6 (1). pp. 25-29.

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Background: Anemia is a common complication of chronic renal failure due to reduce erythropoietin production by kidneys. Anemia treated with recombinant human erythropoietin (rHu-EPO). Pure red cell aplasia (PRCA) due to antibody production against rHu-EPO is a rare but major complication of this drug. Objectives: The aim of this study was to determine the prevalence of PRCA due to antibodies in dialysis patients with resistant anemia who received erythropoietin. Patients and Methods: We studied 128 under maintenance hemodialysis patients more than 3 month in Kashan. In patients with anemia who received erythropoietin with dose requirements based on weight and anemia and without any another cause for anemia,evaluate for PRCA and anti-rHu-EPO antibody level were measured by ELISA. Results: In this research,75 patients (58.6) were male and 53 patients (41.4) were female. The mean age of the patients was 59.05 ± 16.66 years. The result of analysis showed that 55(43) patients had anemia with hemoglobin level less than 10 mg/dL. Only 3 patients had PRCA and antibodies against erythropoietin in serum. There were no correlation between age,gender,cause of renal failure,hemodialysis duration,hemoglobin level,rHu-EPO dose and levels of anti-rHu-EPO antibody serum value. Conclusions: The result of this study indicated that administration of rHu-EPO in dialysis patients afflicted to kidney failure may cause PRCA especially through intravenous injection. However,this change is not statistically significant. © 2017 The Author(s).

Item Type: Article
Additional Information: cited By 0
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Internal Medicine
Depositing User: editor . 2
Date Deposited: 03 Mar 2017 17:35
Last Modified: 03 Mar 2017 17:35
URI: http://eprints.kaums.ac.ir/id/eprint/32

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