Antifungal activity of herbal extracts against Malassezia species

Nazeri, M. and Ata-Bakhshian, R. and Taghizadeh, M. and Talaee, R. and Mahboubi, M. (2015) Antifungal activity of herbal extracts against Malassezia species. Iranian Journal of Dermatology, 18 (71). pp. 10-15.

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Background: Malassezia spp. is an opportunistic dimorphic Basidiomycetous fungi associated with a variety of diseases including dandruff, atopic eczema, pityriasis versicolor, seborrheic dermatitis and folliculitis. It also causes systemic infections in immune compromised patients. The aim of this study was to evaluate the antimicrobial activity of nettle leaves (Urtica dioica), colocynths fruits (Citrullus colocynthis), green tea (Camellia sinensis), burdock root (Arctium lappa) extracts and ketoconazole against 26 isolates of Malassezia spp., isolated from patients with Malassezia infections. Method: Twenty-six (26) Malassezia spp. identified by RFLPPCR, were isolated from patients with Malassezia infections. The antifungal activity was evaluated by micro broth dilution assay. Result: M. globosa (50), M. furfur (46) and M. slooffiae (4) were the isolated strains. There was no significant difference between the minimal inhibitory concentration (MIC) values for colocynth extracts and ketoconazole. Also, the antimicrobial activity of green tea and burdock extracts against Malassezia spp. was not significantly different (P>0.05). The minimal fungicidal concentration (MFC) values for green tea, colocynth extracts and ketoconazole against Malassezia spp. were the same (P>0.05). Conclusion: Further clinical studies are required to determine the efficacy of C. colocynthis ethanol extract, in the treatment of Malassezia skin disorders. © 2015 Iranian Society of Dermatology.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: Arctium lappa extract; Camellia sinensis extract; colocynth extract; DNA 26S; fungal DNA; ketoconazole; plant extract; unclassified drug; Urtica dioica extract, antifungal activity; Arctium lappa; Article; broth dilution; Camellia sinensis; colocynth; colony forming unit; controlled study; fungal detection; fungicidal activity; Malassezia dermatitis; Malassezia furfur; Malassezia globosa; Malassezia slooffiae; minimum fungicidal concentration; minimum inhibitory concentration; nonhuman; plant leaf; polymerase chain reaction; restriction fragment length polymorphism; Urtica dioica
Subjects: Parasitology
Divisions: Faculty of Medicine > Basic Sciences > Department of Parasitological & Mycology
Depositing User: editor . 2
Date Deposited: 07 Mar 2017 20:27
Last Modified: 07 Mar 2017 20:27

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