The effect of silver nanoparticles covered with the Achillea biebersteinii plant extract on angiogenesis of chick chorioallantoic membrane

Zamani-Esmati, Parisa and Baharara, Javad and Iranbakhsh, Alireza and Ramezani, Tayebe (2018) The effect of silver nanoparticles covered with the Achillea biebersteinii plant extract on angiogenesis of chick chorioallantoic membrane. Feyz Journal of Kashan University of Medical Sciences, 21 (6). pp. 553-561.

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Official URL: http://feyz.kaums.ac.ir/article-1-3002-en.html
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Abstract

Background: Angiogenesis is a major event in many diseases such as cancer. Today, using silver nanoparticles in industry and medicine has taken into consideration. The Achillea biebersteinii extract has antibacterial, anti-inflammatory and antioxidant effects. The present study aimed at examining the effects of silver nanoparticles coated with the A. biebersteinii extract on angiogenesis of chick chorioallantoic membrane. Materials and Methods: In this experimental study, 50 fertilized eggs Ross were randomly divided into 5 groups: the sham and experimental groups 1 to 4. In the second day of incubation, the window was opened on eggs and the eggs were treated with 50, 100, 150 and 200 μg/mL silver nanoparticles. At the twelfth day, the samples were photographed and the number and lengths of vessels around the sponges, the length of crown-rump, fetal weight and blood vessels' hemoglobin levels were recorded and compared with the control group. Results: The results showed that the 50 μg/mL of silver nanoparticles had no significant effect on the angiogenesis process. However, 100,150 and 200 μg/mL of the nanoparticles doses-dependently decreased the number, length and content of hemoglobin in the blood vessels. Also, fetal weight and crown-rump in concentrations 150 and 200 μg/mL showed a significant decrease compared with the control group (P<0.01). Conclusion: Silver nanoparticles coated with A. biebersteinii extracts can be considered in the studies of diseases associated with angiogenesis such as cancer.

Item Type: Article
Subjects: Biochemistry, Genetics and Molecular Biology
Divisions: Feyz journal
Depositing User: editor . feyz
Date Deposited: 14 Jan 2018 14:58
Last Modified: 14 Jan 2018 14:58
URI: http://eprints.kaums.ac.ir/id/eprint/3123

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