The antidiabetic effect of L-carnitine in rats: the role of nitric oxide system

Hajian-Shahri, Sh and Hajinezhad, MR and Jahantigh, M and Miri, HR (2017) The antidiabetic effect of L-carnitine in rats: the role of nitric oxide system. Feyz Journal of Kashan University of Medical Sciences, 21 (5). pp. 413-420.


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Background: Nowadays, the use of L-carnitine in the treatment of diabetes is increasing. This study was conducted to investigate the effect of co-administration of L-arginine (precursor for the synthesis of nitric oxide) and nitro-L-arginine (nitric oxide synthesis inhibitor) on antidiabetic activity of L-carnitine in diabetic rats. Materials and Methods: In this study, 50 male rats weighing 180-201g were divided into five groups: (1) non diabetic control rats; (2) untreated diabetic rats; (3) diabetic rats treated with L-carnitine 300 mg/kg (4); diabetic rats treated with L-carnitine 300 mg/kg + L-arginine 300 mg/kg; and (5) diabetic rats treated with L-carnitine (300 mg/kg) + nitro-L-arginine (1mg/kg). Type 1 diabetes was induced by a single intraperitoneal injection of 110 mg/kg body weight alloxan. After 30 days, liver malondialdehyde levels, lipid profile, serum glucose, and glycated hemoglobin serum levels were measured. Results: Blood glucose, liver enzymes, glycated hemoglobin, and liver malondialdehyde levels significantly decreased in diabetic rats treated with L-carnitine compared to the untreated diabetic group (P<0.05). The co-administration of L-arginine and L-carnitine led to a significant decrease in glycated hemoglobin levels and serum glucose, in a manner similar to the group received only L-carnitine. Also, L-arginine and nitro-l-arginine had similar effects on liver lipid peroxidation and serum biochemical parameters. Conclusion: The results suggest that the hypoglycemic effect of L-carnitine is mediated independently from nitric oxide pathways. The interaction between L-carnitine and L-arginine may not be synergistic. So, their combined administration is not recommended for the diabetic patients.

Item Type: Article
Subjects: Physiology
Divisions: Feyz journal
Depositing User: editor . feyz
Date Deposited: 25 Nov 2017 16:11
Last Modified: 25 Nov 2017 16:11

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