Association of the c.-9C>T and c.368A>G transitions in H2BFWT gene with male infertility in an Iranian population

Rafatmanesh, A. and Nikzad, H. and Ebrahimi, A. and Karimian, M. and Zamani, T. (2017) Association of the c.-9C>T and c.368A>G transitions in H2BFWT gene with male infertility in an Iranian population. Andrologia.

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Abstract

The H2BFWT (H2B family, member W, testis specific) gene is a testis-specific histone which is involved in the spermatogenesis process. This study aimed to investigate the association of H2BFWT gene c.-9C>T and c.368A>G polymorphisms with male infertility in an Iranian population. The 232 independent individuals, including 109 infertile men and 123 healthy controls, were recruited from IVF centre (Kashan, Iran). The allele types of c.-9C>T and c.368A>G polymorphisms were detected by using PCR-RFLP method. In overall analysis, we found that the c.-9T (OR: 1.75, 95% CI: 1.04–2.95, p = .035) and c.368G (OR: 1.71, 95% CI: 1.02–2.89, p = .042) alleles are associated with male infertility. The c.-9T allele was also associated with nonobstructive azoospermia (OR: 2.08, 95% CI: 1.01–4.25, p = .046), while c.368G allele was associated with oligozoospermia (OR: 2.10, 95% CI: 1.15–3.85, p = .016). It is concluded that H2BFWT gene c.-9C>T and c.368A>G polymorphisms might be genetic risk factors for idiopathic male infertility.

Item Type: Article
Additional Information: cited By 0; Article in Press
Subjects: Midwifery
Divisions: Faculty of Medicine > Basic Sciences > Department of Anatomy
Depositing User: ART . editor
Date Deposited: 16 Sep 2017 16:40
Last Modified: 16 Sep 2017 16:40
URI: http://eprints.kaums.ac.ir/id/eprint/3038

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