The Effect of Zinc Supplementation on Expressed Levels of Peroxisome Proliferator-Activated Receptor Gamma and Glucose Transporter Type 1 Genes in Newborns of Women with Gestational Diabetes Mellitus

Heidarzadeh, Z. and Samimi, M. and Seifati, S.M. and Ashkezari, M.D. and Ahmadi, S. and Mahmoodi, S. and Aghadavod, E. and Jamilian, M. and Asemi, Z. (2017) The Effect of Zinc Supplementation on Expressed Levels of Peroxisome Proliferator-Activated Receptor Gamma and Glucose Transporter Type 1 Genes in Newborns of Women with Gestational Diabetes Mellitus. Biological Trace Element Research, 175 (2). pp. 271-277.

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Abstract

The current study was designed to determine the beneficial effects of zinc supplementation on expressed levels of peroxisome proliferator-activated receptor gamma (PPAR-γ) and glucose transporter type 1 (GLUT1) genes in newborns of women with gestational diabetes mellitus (GDM). This randomized, double-blind, placebo-controlled clinical trial was performed among 40 women with GDM. Patients were randomly allocated to intake either 233 mg zinc gluconate (containing 30 mg zinc) (n = 20) or a placebo (n = 20) for 6 weeks. PPAR-γ and GLUT1 mRNA levels were quantified in umbilical cord blood of newborns of women with GDM. After 6 weeks of intervention, the change in serum zinc levels was greater in women consuming zinc than in the placebo group (+11.1 ± 13.4 vs. −4.8 ± 17.3 mg/dL, P = 0.002). Quantitative results of RT-PCR demonstrated that compared with the placebo, zinc supplementation resulted in a significant increase of expressed levels of PPAR-γ mRNA (P < 0.001) and GLUT1 mRNA (P < 0.001) in umbilical cord blood of newborns of women with GDM. Taken together, the current study demonstrated that zinc supplementation for 6 weeks among GDM women increased the mRNA levels of PPAR-γ and GLUT1 in their newborns compared with the placebo group. © 2016, Springer Science+Business Media New York.

Item Type: Article
Additional Information: cited By 0
Subjects: Midwifery
Divisions: Faculty of Medicine > Clinical Sciences > Department of , Obstetrics & Gynecology
Depositing User: ART . editor
Date Deposited: 16 Sep 2017 12:36
Last Modified: 16 Sep 2017 12:36
URI: http://eprints.kaums.ac.ir/id/eprint/3030

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