Long-Term Vitamin D Supplementation Affects Metabolic Status in Vitamin D-Deficient Type 2 Diabetic Patients with Coronary Artery Disease

Farrokhian, A. and Raygan, F. and Bahmani, F. and Talari, H.R. and Esfandiari, R. and Esmaillzadeh, A. and Asemi, Z. (2017) Long-Term Vitamin D Supplementation Affects Metabolic Status in Vitamin D-Deficient Type 2 Diabetic Patients with Coronary Artery Disease. The Journal of nutrition, 147 (3). pp. 384-389.

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Abstract

Background: Vitamin D might be beneficial in diabetic patients with coronary artery disease (CAD) through its favorable effects on metabolic profiles and biomarkers of inflammation and oxidative stress. Objective: This study was performed to examine the effects of 6 mo of vitamin D supplementation on metabolic status in diabetic patients with CAD. Methods: This randomized, double-blind, placebo-controlled clinical trial was conducted in 60 vitamin D–deficient diabetic patients with CAD aged 40–85 y. Subjects were randomly assigned into 2 groups to take either 50,000-IU vitamin D supplements (n = 30) or placebo (n = 30) every 2 wk for 6 mo. Fasting blood samples were obtained at the beginning of the study and after the 6-mo intervention to quantify glycemic indicators, lipid concentrations, and biomarkers of inflammation and oxidative stress. Results: Compared with placebo, vitamin D supplementation resulted in significant reductions in fasting plasma glucose (−14.9 ± 7.1 compared with +19.3 ± 7.1 mg/dL; P = 0.001), serum insulin (−2.7 ± 1.1 compared with +1.8 ± 1.1 μIU/mL; P = 0.006), homeostasis model assessment of insulin resistance (−0.7 ± 0.3 compared with +0.5 ± 0.3; P = 0.01), and β cell function (−9.1 ± 4.2 compared with +5.7 ± 4.2; P = 0.01) and a significant increase in serum vitamin D (+6.8 ± 0.9 compared with +0.1 ± 0.9 ng/mL; P < 0.001) and the Quantitative Insulin Sensitivity Check Index (+0.008 ± 0.004 compared with −0.007 ± 0.004; P = 0.01). In addition, changes in serum high-sensitivity C-reactive protein (hs-CRP; −1.0 ± 0.5 compared with +0.6 ± 0.5 μg/mL; P = 0.02), plasma nitric oxide (NO; +7.0 ± 2.0 compared with −4.6 ± 2.0 μmol/L; P < 0.001), total reduced glutathione (GSH; +104 ± 16.4 compared with +24.8 ± 16.4 μmol/L; P = 0.001), and malondialdehyde concentrations (−0.2 ± 0.1 compared with +0.2 ± 0.1 μmol/L; P < 0.001) in the supplemented group were significantly different from the changes in these indicators in the placebo group. Conclusions: Overall, 6 mo of vitamin D supplementation among vitamin D–deficient diabetic patients with CAD had beneficial effects on glycemic control and serum hs-CRP, NO, GSH, and malondialdehyde concentrations. This trial was registered on the Iranian website (www.irct.ir) for registration of clinical trials as IRCT201510315623N56.

Item Type: Article
Additional Information: cited By 3
Subjects: Nutrition
Divisions: Faculty of Medicine > Clinical Sciences > Department of Cardiology
Depositing User: ART . editor
Date Deposited: 08 Oct 2017 18:25
Last Modified: 08 Oct 2017 18:25
URI: http://eprints.kaums.ac.ir/id/eprint/3020

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