ABCB1-C3435T polymorphism and breast cancer risk: A case-control study and a meta-analysis

Sharif, A. and Kheirkhah, D. and Sharif, M.R. and Karimian, M. and Karimian, Z. (2017) ABCB1-C3435T polymorphism and breast cancer risk: A case-control study and a meta-analysis. Journal of B.U.ON., 22 (2). pp. 355-364.

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Abstract

Purpose: To investigate the association of ABCB1-C3435T transition with breast cancer risk which was followed by a meta-analysis. Methods: In a case-control study we collected blood samples from 290 women (including 150 breast cancer patients and 140 healthy controls). ABCB1-C3435T genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. A meta-analysis was performed for a total of 13 eligible studies involving 5,835 cases and 8,178 controls. Results: The results of case-control study revealed a significant association between T allele (OR=1.770, 95%CI=1.236-2.535, p=0.002), CT genotype (OR=1.661, 95%CI=1.017-2.713, p=0.042), and TT genotype (OR=3.399, 95%C1=1.409-8.197, p=0.006) with breast cancer risk. Data from meta-analysis revealed a significant association between ABCB1-C3435T polymorphism and breast cancer risk in allelic (OR=1.243, 95%CI=1.079-1.432, p=0.003), co-dominant (OR=1.349, 95%CI=1.042-1.746, p=0.023), dominant (OR=1.204, 95%CI=1.019-1.422, p=0.029), and recessive (OR=1.226, 9S%C1-1.0U-1.488, p=0.039) models. Conclusions: The results suggest that the ABCB1-C3435T gene polymorphism might be a genetic risk factor and a potential biomarker for breast cancer.

Item Type: Article
Additional Information: cited By 0
Subjects: Medicine
Divisions: Faculty of Medicine > Clinical Sciences > Department of Infectious Diseases
Depositing User: ART . editor
Date Deposited: 16 Sep 2017 17:04
Last Modified: 16 Sep 2017 17:04
URI: http://eprints.kaums.ac.ir/id/eprint/3014

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