Prenatal exposure to noise stress: Anxiety, impaired spatial memory, and deteriorated hippocampal plasticity in postnatal life

Barzegar, M. and Sajjadi, F.S. and Talaei, S.A. and Hamidi, G.A. and Salami, M. (2015) Prenatal exposure to noise stress: Anxiety, impaired spatial memory, and deteriorated hippocampal plasticity in postnatal life. Hippocampus, 25 (2). pp. 187-196.

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Abstract

Sound pollution is known as an annoying phenomenon in modern life. Especially, development of organisms during fetal life is more sensitive to environmental tensions. To address a link between the behavioral and electrophysiological aspects of brain function with action of hypothalamus-pituitary-adrenal (HPA) axis in stressed animals, this study was carried out on the male Wistar rats prenatally exposed to sound stress. Groups of pregnant rats were exposed to noise stress for 1, 2, and 4 hour(s). The degree of anxiety and the spatial memory were evaluated by elevated plus maze and Morris water maze, respectively. Basic synaptic activity and long-term potentiation (LTP) induction were assessed in the CA3-CA1 pathway of hippocampus. The serum level of corticosterone was measured in the pregnant mothers and the offspring. The behavioral experiments appeared that the stressed animals performed considerably weaker than the control rats. The prenatal stress negatively affected the basic synaptic responses and led to a lower level of LTP. The pregnant animals showed an increased serum corticosterone in comparison with the nonpregnant females. Also the offspring exposed to the noise stress had a more elevated level of corticosterone than the control rats. Our findings indicate that the corticosterone concentration changes markedly coincides the results of behavioral and electrophysiological experiments. We conclude that, similar to other environmental stresses, the sound stress during fetal life efficiently disturbs both cognitive abilities and synaptic activities. The changes in action of HPA axis may contribute to problems of the brain function in the prenatally stress exposed animals. © 2014 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 13
Uncontrolled Keywords: corticosterone; corticosterone, acoustic stress; animal experiment; anxiety; Article; controlled study; corticosterone blood level; electrophysiology; elevated T-maze test; female; hippocampus; hypothalamus hypophysis adrenal system; long term potentiation; male; Morris water maze test; nerve cell plasticity; nonhuman; perinatal period; prenatal exposure; priority journal; rat; spatial memory; adverse effects; animal; anxiety disorder; blood; disease model; excitatory postsynaptic potential; maze test; Memory Disorders; mental stress; microelectrode; noise; pathophysiology; physiology; pregnancy; randomization; spatial memory; synaptic transmission; Wistar rat, Animals; Anxiety Disorders; Corticosterone; Disease Models, Animal; Excitatory Postsynaptic Potentials; Female; Hippocampus; Long-Term Potentiation; Male; Maze Learning; Memory Disorders; Microelectrodes; Noise; Pregnancy; Prenatal Exposure Delayed Effects; Random Allocation; Rats, Wistar; Spatial Memory; Stress, Psychological; Synaptic Transmission
Subjects: Physiology
Neuroscience
Divisions: Faculty of Medicine > Basic Sciences > Department of physiology
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 14:05
Last Modified: 11 Mar 2017 16:23
URI: http://eprints.kaums.ac.ir/id/eprint/288

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