Cervical length versus vaginal PH in the second trimester as preterm birth predictor

Foroozanfard, F. and Tabassi, Z. and Mesdaghinia, E. and Sehat, M. and Mahdian, M. (2015) Cervical length versus vaginal PH in the second trimester as preterm birth predictor. Pakistan Journal of Medical Sciences, 31 (2). pp. 374-378.

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Objective: To evaluate diagnostic value of vaginal pH and cervical length measurement in the second trimester of pregnancy as a preterm labor (PTL) predictor. Methods: During a prospective cohort study 438 uncomplicated singleton pregnant women between 18 and 24 weeks of gestation were assessed regarding vaginal PH and cervical length. Vaginal pH was measured using Ph-indicator strips and cervical length was determined using transvaginal ultrasound. The cut-off values for vaginal PH and cervical length were defined as 5 and <30 mm respectively. Results: Vaginal pH of 5 and above was found in 162/438 women (37) while cervical length <30mm was found in 38/438 (8.7). The incidence of PTL < 37 weeks was 87/438 (19.9) while the incidence of early (PTL <34 weeks) was 51/438 (11.6). Predictive value of higher vaginal PH was significantly more (31) than vaginal PH<5 (13) in predicting PTL. As a result, alkaline vaginal PH significantly increases the odds of preterm labor (OR=3.06). Shortened cervical length is better predictor of PTL than higher vaginal PH with positive predictive value of 71 and negative predictive value of 85. Cervical length less than 30 mm nearly 14-fold increases odds of preterm birth (OR=13.9). Conclusion: Compared to alkaline vaginal PH, shortened cervical length has better value to predict PTL overall. However, regarding early or late PTL, vaginal PH is more accurate to predict late PTL, while cervical length measurement is more appropriate to predict early PTL (<34 weeks). © 2015, Professional Medical Publications. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: accuracy; adult; alkalinity; Article; cervical length measurement; clinical evaluation; cohort analysis; female; gestational age; human; major clinical study; maternal age; predictive value; pregnant woman; premature labor; second trimester pregnancy; transvaginal echography; vagina pH
Subjects: Health Professions
Divisions: Faculty of Para medicine > Department of Management Anesthesia
Depositing User: editor . 2
Date Deposited: 08 Mar 2017 14:03
Last Modified: 08 Mar 2017 21:40
URI: http://eprints.kaums.ac.ir/id/eprint/286

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